Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes

Abstract The potential photothermal bactericidal activity of hydrophilic functionalized poly ethylene glycol (PEG)-gold nanorods (GNR) and hydrophobic functionalized polystyrene (PS)-GNR was evaluated towards strains of Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes) by meas...

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Autores principales:	Nouf N. Mahmoud, Alaaldin M. Alkilany, Enam A. Khalil, Amal G. Al-Bakri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d39a5a05fd6b4f18875b289582928b98
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spelling	oai:doaj.org-article:d39a5a05fd6b4f18875b289582928b982021-12-02T15:08:06ZNano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes10.1038/s41598-018-24837-72045-2322https://doaj.org/article/d39a5a05fd6b4f18875b289582928b982018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24837-7https://doaj.org/toc/2045-2322Abstract The potential photothermal bactericidal activity of hydrophilic functionalized poly ethylene glycol (PEG)-gold nanorods (GNR) and hydrophobic functionalized polystyrene (PS)-GNR was evaluated towards strains of Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes) by measuring the percentage reduction of bacterial viable count upon GNR excitation with a near infra-red (NIR) laser beam. Our results suggest that functionalized GNR had a minimal bactericidal activity against S. aureus and P. acnes (≤85%, i.e. ≤1 log10 cycle reduction of bacterial viable count). However, the local heat generated upon exciting the functionalized GNR with NIR laser beam has a significant photothermal ablation effect (≥99.99%, i.e. ≥4 log10 cycles reduction of bacterial viable count). Such photothermolysis effect could potentiate the antibacterial activity of GNR, which may call for minimum concentration and side effects of these nanotherapeutics.Nouf N. MahmoudAlaaldin M. AlkilanyEnam A. KhalilAmal G. Al-BakriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nouf N. Mahmoud Alaaldin M. Alkilany Enam A. Khalil Amal G. Al-Bakri Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
description	Abstract The potential photothermal bactericidal activity of hydrophilic functionalized poly ethylene glycol (PEG)-gold nanorods (GNR) and hydrophobic functionalized polystyrene (PS)-GNR was evaluated towards strains of Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes) by measuring the percentage reduction of bacterial viable count upon GNR excitation with a near infra-red (NIR) laser beam. Our results suggest that functionalized GNR had a minimal bactericidal activity against S. aureus and P. acnes (≤85%, i.e. ≤1 log10 cycle reduction of bacterial viable count). However, the local heat generated upon exciting the functionalized GNR with NIR laser beam has a significant photothermal ablation effect (≥99.99%, i.e. ≥4 log10 cycles reduction of bacterial viable count). Such photothermolysis effect could potentiate the antibacterial activity of GNR, which may call for minimum concentration and side effects of these nanotherapeutics.
format	article
author	Nouf N. Mahmoud Alaaldin M. Alkilany Enam A. Khalil Amal G. Al-Bakri
author_facet	Nouf N. Mahmoud Alaaldin M. Alkilany Enam A. Khalil Amal G. Al-Bakri
author_sort	Nouf N. Mahmoud
title	Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
title_short	Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
title_full	Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
title_fullStr	Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
title_full_unstemmed	Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
title_sort	nano-photothermal ablation effect of hydrophilic and hydrophobic functionalized gold nanorods on staphylococcus aureus and propionibacterium acnes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d39a5a05fd6b4f18875b289582928b98
work_keys_str_mv	AT noufnmahmoud nanophotothermalablationeffectofhydrophilicandhydrophobicfunctionalizedgoldnanorodsonstaphylococcusaureusandpropionibacteriumacnes AT alaaldinmalkilany nanophotothermalablationeffectofhydrophilicandhydrophobicfunctionalizedgoldnanorodsonstaphylococcusaureusandpropionibacteriumacnes AT enamakhalil nanophotothermalablationeffectofhydrophilicandhydrophobicfunctionalizedgoldnanorodsonstaphylococcusaureusandpropionibacteriumacnes AT amalgalbakri nanophotothermalablationeffectofhydrophilicandhydrophobicfunctionalizedgoldnanorodsonstaphylococcusaureusandpropionibacteriumacnes
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Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes

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