Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors

Abstract To present the feasibility of a dynamic whole-body (DWB) 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors (WD-NETs). Sixty-one patients who underwent a DWB 68Ga-DOTATOC-PET/CT for a histologically proven/highly suspected WD-NET were prospectively in...

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Autores principales:	Philippe Thuillier, David Bourhis, Jean Philippe Metges, Romain Le Pennec, Karim Amrane, Ulrike Schick, Frédérique Blanc-Beguin, Simon Hennebicq, Pierre-Yves Salaun, Véronique Kerlan, Nicolas Karakatsanis, Ronan Abgral
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d39da825f175412f822a6780af2476cf
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spelling	oai:doaj.org-article:d39da825f175412f822a6780af2476cf2021-12-02T13:20:04ZProspective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors10.1038/s41598-021-83965-92045-2322https://doaj.org/article/d39da825f175412f822a6780af2476cf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83965-9https://doaj.org/toc/2045-2322Abstract To present the feasibility of a dynamic whole-body (DWB) 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors (WD-NETs). Sixty-one patients who underwent a DWB 68Ga-DOTATOC-PET/CT for a histologically proven/highly suspected WD-NET were prospectively included. The acquisition consisted in single-bed dynamic acquisition centered on the heart, followed by the DWB and static acquisitions. For liver, spleen and tumor (1–5/patient), Ki values (in ml/min/100 ml) were calculated according to Patlak's analysis and tumor-to-liver (TLR-Ki) and tumor-to-spleen ratios (TSR-Ki) were recorded. Ki-based parameters were compared to static parameters (SUVmax/SUVmean, TLR/TSRmean, according to liver/spleen SUVmean), in the whole-cohort and according to the PET system (analog/digital). A correlation analysis between SUVmean/Ki was performed using linear and non-linear regressions. Ki-liver was not influenced by the PET system used, unlike SUVmax/SUVmean. The regression analysis showed a non-linear relation between Ki/SUVmean (R2 = 0.55,0.68 and 0.71 for liver, spleen and tumor uptake, respectively) and a linear relation between TLRmean/TLR-Ki (R2 = 0.75). These results were not affected by the PET system, on the contrary of the relation between TSRmean/TSR-Ki (R2 = 0.94 and 0.73 using linear and non-linear regressions in digital and analog systems, respectively). Our study is the first showing the feasibility of a DWB 68Ga-DOTATOC-PET/CT acquisition in WD-NETs.Philippe ThuillierDavid BourhisJean Philippe MetgesRomain Le PennecKarim AmraneUlrike SchickFrédérique Blanc-BeguinSimon HennebicqPierre-Yves SalaunVéronique KerlanNicolas KarakatsanisRonan AbgralNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philippe Thuillier David Bourhis Jean Philippe Metges Romain Le Pennec Karim Amrane Ulrike Schick Frédérique Blanc-Beguin Simon Hennebicq Pierre-Yves Salaun Véronique Kerlan Nicolas Karakatsanis Ronan Abgral Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors
description	Abstract To present the feasibility of a dynamic whole-body (DWB) 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors (WD-NETs). Sixty-one patients who underwent a DWB 68Ga-DOTATOC-PET/CT for a histologically proven/highly suspected WD-NET were prospectively included. The acquisition consisted in single-bed dynamic acquisition centered on the heart, followed by the DWB and static acquisitions. For liver, spleen and tumor (1–5/patient), Ki values (in ml/min/100 ml) were calculated according to Patlak's analysis and tumor-to-liver (TLR-Ki) and tumor-to-spleen ratios (TSR-Ki) were recorded. Ki-based parameters were compared to static parameters (SUVmax/SUVmean, TLR/TSRmean, according to liver/spleen SUVmean), in the whole-cohort and according to the PET system (analog/digital). A correlation analysis between SUVmean/Ki was performed using linear and non-linear regressions. Ki-liver was not influenced by the PET system used, unlike SUVmax/SUVmean. The regression analysis showed a non-linear relation between Ki/SUVmean (R2 = 0.55,0.68 and 0.71 for liver, spleen and tumor uptake, respectively) and a linear relation between TLRmean/TLR-Ki (R2 = 0.75). These results were not affected by the PET system, on the contrary of the relation between TSRmean/TSR-Ki (R2 = 0.94 and 0.73 using linear and non-linear regressions in digital and analog systems, respectively). Our study is the first showing the feasibility of a DWB 68Ga-DOTATOC-PET/CT acquisition in WD-NETs.
format	article
author	Philippe Thuillier David Bourhis Jean Philippe Metges Romain Le Pennec Karim Amrane Ulrike Schick Frédérique Blanc-Beguin Simon Hennebicq Pierre-Yves Salaun Véronique Kerlan Nicolas Karakatsanis Ronan Abgral
author_facet	Philippe Thuillier David Bourhis Jean Philippe Metges Romain Le Pennec Karim Amrane Ulrike Schick Frédérique Blanc-Beguin Simon Hennebicq Pierre-Yves Salaun Véronique Kerlan Nicolas Karakatsanis Ronan Abgral
author_sort	Philippe Thuillier
title	Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors
title_short	Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors
title_full	Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors
title_fullStr	Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors
title_full_unstemmed	Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors
title_sort	prospective study of dynamic whole-body 68ga-dotatoc-pet/ct acquisition in patients with well-differentiated neuroendocrine tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d39da825f175412f822a6780af2476cf
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Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors

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