Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme...

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Autores principales:	Lorella Marselli, Emanuele Bosi, Carmela De Luca, Silvia Del Guerra, Marta Tesi, Mara Suleiman, Piero Marchetti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arginase 2 polyamines pancreatic islets beta cells type 2 diabetes Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d39db0ce76f1418cb7eeec62287d27f2
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spelling	oai:doaj.org-article:d39db0ce76f1418cb7eeec62287d27f22021-11-25T17:53:24ZArginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes10.3390/ijms2222120991422-00671661-6596https://doaj.org/article/d39db0ce76f1418cb7eeec62287d27f22021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12099https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes.Lorella MarselliEmanuele BosiCarmela De LucaSilvia Del GuerraMarta TesiMara SuleimanPiero MarchettiMDPI AGarticlearginase 2polyaminespancreatic isletsbeta cellstype 2 diabetesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12099, p 12099 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arginase 2 polyamines pancreatic islets beta cells type 2 diabetes Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	arginase 2 polyamines pancreatic islets beta cells type 2 diabetes Biology (General) QH301-705.5 Chemistry QD1-999 Lorella Marselli Emanuele Bosi Carmela De Luca Silvia Del Guerra Marta Tesi Mara Suleiman Piero Marchetti Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
description	Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes.
format	article
author	Lorella Marselli Emanuele Bosi Carmela De Luca Silvia Del Guerra Marta Tesi Mara Suleiman Piero Marchetti
author_facet	Lorella Marselli Emanuele Bosi Carmela De Luca Silvia Del Guerra Marta Tesi Mara Suleiman Piero Marchetti
author_sort	Lorella Marselli
title	Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_short	Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_full	Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_fullStr	Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_full_unstemmed	Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_sort	arginase 2 and polyamines in human pancreatic beta cells: possible role in the pathogenesis of type 2 diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d39db0ce76f1418cb7eeec62287d27f2
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Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

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