The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

Mutations in superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS). Here the authors present the SOD1 crystal structure bound to the small cysteine-reactive molecule ebselen and show that ebselen is a chaperone for SOD1.

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Autores principales:	Michael J. Capper, Gareth S. A. Wright, Letizia Barbieri, Enrico Luchinat, Eleonora Mercatelli, Luke McAlary, Justin J. Yerbury, Paul M. O’Neill, Svetlana V. Antonyuk, Lucia Banci, S. Samar Hasnain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d39dd025e5674f268976de0edbd8107d
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spelling	oai:doaj.org-article:d39dd025e5674f268976de0edbd8107d2021-12-02T17:31:13ZThe cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation10.1038/s41467-018-04114-x2041-1723https://doaj.org/article/d39dd025e5674f268976de0edbd8107d2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04114-xhttps://doaj.org/toc/2041-1723Mutations in superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS). Here the authors present the SOD1 crystal structure bound to the small cysteine-reactive molecule ebselen and show that ebselen is a chaperone for SOD1.Michael J. CapperGareth S. A. WrightLetizia BarbieriEnrico LuchinatEleonora MercatelliLuke McAlaryJustin J. YerburyPaul M. O’NeillSvetlana V. AntonyukLucia BanciS. Samar HasnainNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Capper Gareth S. A. Wright Letizia Barbieri Enrico Luchinat Eleonora Mercatelli Luke McAlary Justin J. Yerbury Paul M. O’Neill Svetlana V. Antonyuk Lucia Banci S. Samar Hasnain The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
description	Mutations in superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS). Here the authors present the SOD1 crystal structure bound to the small cysteine-reactive molecule ebselen and show that ebselen is a chaperone for SOD1.
format	article
author	Michael J. Capper Gareth S. A. Wright Letizia Barbieri Enrico Luchinat Eleonora Mercatelli Luke McAlary Justin J. Yerbury Paul M. O’Neill Svetlana V. Antonyuk Lucia Banci S. Samar Hasnain
author_facet	Michael J. Capper Gareth S. A. Wright Letizia Barbieri Enrico Luchinat Eleonora Mercatelli Luke McAlary Justin J. Yerbury Paul M. O’Neill Svetlana V. Antonyuk Lucia Banci S. Samar Hasnain
author_sort	Michael J. Capper
title	The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
title_short	The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
title_full	The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
title_fullStr	The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
title_full_unstemmed	The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
title_sort	cysteine-reactive small molecule ebselen facilitates effective sod1 maturation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d39dd025e5674f268976de0edbd8107d
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The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

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