Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses

ABSTRACT The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence of the CD4 receptor at the cell surface, primary Envs sample a “closed” conformation that occludes CD4-induced (...

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Autores principales: Jonathan Richard, Jérémie Prévost, Amy E. Baxter, Benjamin von Bredow, Shilei Ding, Halima Medjahed, Gloria G. Delgado, Nathalie Brassard, Christina M. Stürzel, Frank Kirchhoff, Beatrice H. Hahn, Matthew S. Parsons, Daniel E. Kaufmann, David T. Evans, Andrés Finzi
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
A32
ADCC
ADCC assay
CD4i Abs
Env
granzyme B assay
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/d3a266c684ee410b80fb7ec26d557ad4
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https://doaj.org/article/d3a266c684ee410b80fb7ec26d557ad4

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