Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma

(1) Background: Prognostic grade group (PGG) is an important prognostic parameter in prostate cancer that guides therapeutic decisions. The cribriform pattern and intraductal carcinoma (IDC) are two histological patterns, that have additional prognostic significance. However, discrepancies exist reg...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vasiliki Tzelepi, Ioanna Maria Grypari, Souzana Logotheti, Stavros Kontogiannis, Panagiotis Kallidonis, Maria Melachrinou, Vasiliki Zolota
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prognostic grade group Gleason Score intraductal carcinoma cribriform pattern Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d3a9fcab99c34d8b96aa865cb4598cee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d3a9fcab99c34d8b96aa865cb4598cee
record_format	dspace
spelling	oai:doaj.org-article:d3a9fcab99c34d8b96aa865cb4598cee2021-11-11T15:33:29ZContemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma10.3390/cancers132154542072-6694https://doaj.org/article/d3a9fcab99c34d8b96aa865cb4598cee2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5454https://doaj.org/toc/2072-6694(1) Background: Prognostic grade group (PGG) is an important prognostic parameter in prostate cancer that guides therapeutic decisions. The cribriform pattern and intraductal carcinoma (IDC) are two histological patterns, that have additional prognostic significance. However, discrepancies exist regarding the handling of IDC according to the guidelines published by two international genitourinary pathology societies. Furthermore, whether, in addition to its presence, the amount of IDC is also of importance has not been studied before. Lastly, the handling of tertiary patterns has also been a matter of debate in the literature. (2) Methods: A total of 129 prostatectomy cases were retrieved and a detailed histopathologic analysis was performed. (3) Results: Two cases (1.6%) upgraded their PGG, when IDC was incorporated in the grading system. The presence and the amount of IDC, as well as the presence of cribriform carcinoma were associated with adverse pathologic characteristics. Interestingly, in six cases (4.7%) there was a difference in PGG when using the different guidelines regarding the handling of tertiary patterns. In total, 6.2% of the cases would be assigned a different grade depending on the guidelines followed. (4) Conclusions: These findings highlight a potential area of confusion among pathologists and clinicians and underscore the need for a consensus grading system.Vasiliki TzelepiIoanna Maria GrypariSouzana LogothetiStavros KontogiannisPanagiotis KallidonisMaria MelachrinouVasiliki ZolotaMDPI AGarticleprognostic grade groupGleason Scoreintraductal carcinomacribriform patternNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5454, p 5454 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prognostic grade group Gleason Score intraductal carcinoma cribriform pattern Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	prognostic grade group Gleason Score intraductal carcinoma cribriform pattern Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Vasiliki Tzelepi Ioanna Maria Grypari Souzana Logotheti Stavros Kontogiannis Panagiotis Kallidonis Maria Melachrinou Vasiliki Zolota Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma
description	(1) Background: Prognostic grade group (PGG) is an important prognostic parameter in prostate cancer that guides therapeutic decisions. The cribriform pattern and intraductal carcinoma (IDC) are two histological patterns, that have additional prognostic significance. However, discrepancies exist regarding the handling of IDC according to the guidelines published by two international genitourinary pathology societies. Furthermore, whether, in addition to its presence, the amount of IDC is also of importance has not been studied before. Lastly, the handling of tertiary patterns has also been a matter of debate in the literature. (2) Methods: A total of 129 prostatectomy cases were retrieved and a detailed histopathologic analysis was performed. (3) Results: Two cases (1.6%) upgraded their PGG, when IDC was incorporated in the grading system. The presence and the amount of IDC, as well as the presence of cribriform carcinoma were associated with adverse pathologic characteristics. Interestingly, in six cases (4.7%) there was a difference in PGG when using the different guidelines regarding the handling of tertiary patterns. In total, 6.2% of the cases would be assigned a different grade depending on the guidelines followed. (4) Conclusions: These findings highlight a potential area of confusion among pathologists and clinicians and underscore the need for a consensus grading system.
format	article
author	Vasiliki Tzelepi Ioanna Maria Grypari Souzana Logotheti Stavros Kontogiannis Panagiotis Kallidonis Maria Melachrinou Vasiliki Zolota
author_facet	Vasiliki Tzelepi Ioanna Maria Grypari Souzana Logotheti Stavros Kontogiannis Panagiotis Kallidonis Maria Melachrinou Vasiliki Zolota
author_sort	Vasiliki Tzelepi
title	Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma
title_short	Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma
title_full	Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma
title_fullStr	Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma
title_full_unstemmed	Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma
title_sort	contemporary grading of prostate cancer: the impact of grading criteria and the significance of the amount of intraductal carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d3a9fcab99c34d8b96aa865cb4598cee
work_keys_str_mv	AT vasilikitzelepi contemporarygradingofprostatecancertheimpactofgradingcriteriaandthesignificanceoftheamountofintraductalcarcinoma AT ioannamariagrypari contemporarygradingofprostatecancertheimpactofgradingcriteriaandthesignificanceoftheamountofintraductalcarcinoma AT souzanalogotheti contemporarygradingofprostatecancertheimpactofgradingcriteriaandthesignificanceoftheamountofintraductalcarcinoma AT stavroskontogiannis contemporarygradingofprostatecancertheimpactofgradingcriteriaandthesignificanceoftheamountofintraductalcarcinoma AT panagiotiskallidonis contemporarygradingofprostatecancertheimpactofgradingcriteriaandthesignificanceoftheamountofintraductalcarcinoma AT mariamelachrinou contemporarygradingofprostatecancertheimpactofgradingcriteriaandthesignificanceoftheamountofintraductalcarcinoma AT vasilikizolota contemporarygradingofprostatecancertheimpactofgradingcriteriaandthesignificanceoftheamountofintraductalcarcinoma
_version_	1718435211866275840

Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma

Ejemplares similares