Age-related changes of ocular parameters in Korean subjects

Dae Woong Lee1, Joon Mo Kim1, Chul Young Choi1, Donghun Shin2, Ki Ho Park3, Jung Gon Cho41Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea; 2School of Medicine, University of Queensland, Brisbane, Queensland, Australia; 3Department of Op...

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Autores principales:	Dae Woong Lee, Joon Mo Kim, Chul Young Choi, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d3aa55a93a004cc7bc5845df7b7f857d
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spelling	oai:doaj.org-article:d3aa55a93a004cc7bc5845df7b7f857d2021-12-02T07:42:27ZAge-related changes of ocular parameters in Korean subjects1177-54671177-5483https://doaj.org/article/d3aa55a93a004cc7bc5845df7b7f857d2010-07-01T00:00:00Zhttp://www.dovepress.com/age-related-changes-of-ocular-parameters-in-korean-subjects-a4780https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Dae Woong Lee1, Joon Mo Kim1, Chul Young Choi1, Donghun Shin2, Ki Ho Park3, Jung Gon Cho41Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea; 2School of Medicine, University of Queensland, Brisbane, Queensland, Australia; 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; 4Yebon Eye Clinic, Seoul, KoreaAims: To evaluate the age-related variations of ocular parameters in Korean subjects.Methods: We recruited 314 normal subjects who visited the department of &shy;Ophthalmology between January 2007 and October 2007. Refraction, axial length, corneal curvature, white-to-white distance, anterior chamber depth, corneal endothelial cell density, and retinal nerve fiber layer (RNFL) thickness were measured using auto-refractive keratometer, intraocular lens master, noncontact specular microscope, and optical coherence tomography.Result: In correlation analysis, from 19 to 82 years, hyperopic shift showed a strong positive statistical correlation with age (r = 0.553, P &lt; 0.001). Corneal curvatures increased (r = 0.221, P &lt; 0.001), while axial length (r = -0.506, P &lt; 0.001), anterior chamber depth (r = -0.491, P &lt; 0.001) and white-to-white distance (r = -0.205, P &lt; 0.001) decreased with age. Also, &shy;corneal endothelial cell density was lower in older patients than in younger patients (r = -0.409, P &lt; 0.001). Compared to younger patients, RNFL thickness was lower in the older patients as well, in all quadrants (superior, r = -0.283, P &lt; 0.001; inferior, r = -0.230, P &lt; 0.001; nasal, r = 0.025, P = 0.676; and temporal, r = -0.393, P &lt; 0.001). According to multiple regression analysis, out of the six parameters measured, only hyperopic shift, anterior chamber depth and corneal endothelial cell density (P &lt; 0.05) had statistically significant &shy;correlation with age.Conclusion: Some of the ocular parameters changed with aging. Hyperopic shift, shallowing anterior chamber depth, and reduction of corneal endothelial cell density were only definitely related to age.Keywords: corneal endothelial cell density, hyperopic, corneal curvatures, axial length, anterior chamber depth Dae Woong LeeJoon Mo KimChul Young Choiet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 725-730 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Dae Woong Lee Joon Mo Kim Chul Young Choi et al Age-related changes of ocular parameters in Korean subjects
description	Dae Woong Lee1, Joon Mo Kim1, Chul Young Choi1, Donghun Shin2, Ki Ho Park3, Jung Gon Cho41Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea; 2School of Medicine, University of Queensland, Brisbane, Queensland, Australia; 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; 4Yebon Eye Clinic, Seoul, KoreaAims: To evaluate the age-related variations of ocular parameters in Korean subjects.Methods: We recruited 314 normal subjects who visited the department of &shy;Ophthalmology between January 2007 and October 2007. Refraction, axial length, corneal curvature, white-to-white distance, anterior chamber depth, corneal endothelial cell density, and retinal nerve fiber layer (RNFL) thickness were measured using auto-refractive keratometer, intraocular lens master, noncontact specular microscope, and optical coherence tomography.Result: In correlation analysis, from 19 to 82 years, hyperopic shift showed a strong positive statistical correlation with age (r = 0.553, P &lt; 0.001). Corneal curvatures increased (r = 0.221, P &lt; 0.001), while axial length (r = -0.506, P &lt; 0.001), anterior chamber depth (r = -0.491, P &lt; 0.001) and white-to-white distance (r = -0.205, P &lt; 0.001) decreased with age. Also, &shy;corneal endothelial cell density was lower in older patients than in younger patients (r = -0.409, P &lt; 0.001). Compared to younger patients, RNFL thickness was lower in the older patients as well, in all quadrants (superior, r = -0.283, P &lt; 0.001; inferior, r = -0.230, P &lt; 0.001; nasal, r = 0.025, P = 0.676; and temporal, r = -0.393, P &lt; 0.001). According to multiple regression analysis, out of the six parameters measured, only hyperopic shift, anterior chamber depth and corneal endothelial cell density (P &lt; 0.05) had statistically significant &shy;correlation with age.Conclusion: Some of the ocular parameters changed with aging. Hyperopic shift, shallowing anterior chamber depth, and reduction of corneal endothelial cell density were only definitely related to age.Keywords: corneal endothelial cell density, hyperopic, corneal curvatures, axial length, anterior chamber depth
format	article
author	Dae Woong Lee Joon Mo Kim Chul Young Choi et al
author_facet	Dae Woong Lee Joon Mo Kim Chul Young Choi et al
author_sort	Dae Woong Lee
title	Age-related changes of ocular parameters in Korean subjects
title_short	Age-related changes of ocular parameters in Korean subjects
title_full	Age-related changes of ocular parameters in Korean subjects
title_fullStr	Age-related changes of ocular parameters in Korean subjects
title_full_unstemmed	Age-related changes of ocular parameters in Korean subjects
title_sort	age-related changes of ocular parameters in korean subjects
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/d3aa55a93a004cc7bc5845df7b7f857d
work_keys_str_mv	AT daewoonglee agerelatedchangesofocularparametersinkoreansubjects AT joonmokim agerelatedchangesofocularparametersinkoreansubjects AT chulyoungchoi agerelatedchangesofocularparametersinkoreansubjects AT etal agerelatedchangesofocularparametersinkoreansubjects
_version_	1718399249372151808

Age-related changes of ocular parameters in Korean subjects

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