Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation

Abstract Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed po...

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Autores principales:	Chengcheng Niu, Yan Xu, Senbo An, Ming Zhang, Yihe Hu, Long Wang, Qinghai Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d3aa6356f1da424b9545065dfc93cd09
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spelling	oai:doaj.org-article:d3aa6356f1da424b9545065dfc93cd092021-12-02T12:32:57ZNear-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation10.1038/s41598-017-06122-12045-2322https://doaj.org/article/d3aa6356f1da424b9545065dfc93cd092017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06122-1https://doaj.org/toc/2045-2322Abstract Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe3O4), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe3O4/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent. After in vitro treatment of MCF-7 breast cancer cells with Fe3O4/ICG@PLGA/PFP NPs and NIR laser irradiation, histology and electron microscopy confirmed severe damage to the cells and the formation of many microbubbles with iron particles at the edge or outside of the microbubbles. In vivo experiments in mice with MCF-7 tumors demonstrated that Fe3O4/ICG@PLGA/PFP NPs could achieve tumor ablation upon NIR laser irradiation with minimal toxicity to non-irradiated tissues. Together, our results indicate that Fe3O4/ICG@PLGA/PFP NPs can be used as effective nanotheranostic agents for tumor ablation.Chengcheng NiuYan XuSenbo AnMing ZhangYihe HuLong WangQinghai PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chengcheng Niu Yan Xu Senbo An Ming Zhang Yihe Hu Long Wang Qinghai Peng Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation
description	Abstract Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe3O4), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe3O4/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent. After in vitro treatment of MCF-7 breast cancer cells with Fe3O4/ICG@PLGA/PFP NPs and NIR laser irradiation, histology and electron microscopy confirmed severe damage to the cells and the formation of many microbubbles with iron particles at the edge or outside of the microbubbles. In vivo experiments in mice with MCF-7 tumors demonstrated that Fe3O4/ICG@PLGA/PFP NPs could achieve tumor ablation upon NIR laser irradiation with minimal toxicity to non-irradiated tissues. Together, our results indicate that Fe3O4/ICG@PLGA/PFP NPs can be used as effective nanotheranostic agents for tumor ablation.
format	article
author	Chengcheng Niu Yan Xu Senbo An Ming Zhang Yihe Hu Long Wang Qinghai Peng
author_facet	Chengcheng Niu Yan Xu Senbo An Ming Zhang Yihe Hu Long Wang Qinghai Peng
author_sort	Chengcheng Niu
title	Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation
title_short	Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation
title_full	Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation
title_fullStr	Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation
title_full_unstemmed	Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation
title_sort	near-infrared induced phase-shifted icg/fe3o4 loaded plga nanoparticles for photothermal tumor ablation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d3aa6356f1da424b9545065dfc93cd09
work_keys_str_mv	AT chengchengniu nearinfraredinducedphaseshiftedicgfe3o4loadedplgananoparticlesforphotothermaltumorablation AT yanxu nearinfraredinducedphaseshiftedicgfe3o4loadedplgananoparticlesforphotothermaltumorablation AT senboan nearinfraredinducedphaseshiftedicgfe3o4loadedplgananoparticlesforphotothermaltumorablation AT mingzhang nearinfraredinducedphaseshiftedicgfe3o4loadedplgananoparticlesforphotothermaltumorablation AT yihehu nearinfraredinducedphaseshiftedicgfe3o4loadedplgananoparticlesforphotothermaltumorablation AT longwang nearinfraredinducedphaseshiftedicgfe3o4loadedplgananoparticlesforphotothermaltumorablation AT qinghaipeng nearinfraredinducedphaseshiftedicgfe3o4loadedplgananoparticlesforphotothermaltumorablation
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Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation

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