SARS-CoV-2 viral load is associated with increased disease severity and mortality
In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflam...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d3b04d9a629f44488b9f26c98ed75ef0 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d3b04d9a629f44488b9f26c98ed75ef0 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d3b04d9a629f44488b9f26c98ed75ef02021-12-02T14:42:47ZSARS-CoV-2 viral load is associated with increased disease severity and mortality10.1038/s41467-020-19057-52041-1723https://doaj.org/article/d3b04d9a629f44488b9f26c98ed75ef02020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19057-5https://doaj.org/toc/2041-1723In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.Jesse FajnzylberJames ReganKendyll CoxenHeather CorryColline WongAlexandra RosenthalDaniel WorrallFrancoise GiguelAlicja Piechocka-TrochaCaroline AtyeoStephanie FischingerAndrew ChanKeith T. FlahertyKathryn HallMichael DouganEdward T. RyanElizabeth GillespieRida ChishtiYijia LiNikolaus JilgDusan HanidziarRebecca M. BaronLindsey BadenAthe M. TsibrisKatrina A. ArmstrongDaniel R. KuritzkesGalit AlterBruce D. WalkerXu YuJonathan Z. LiThe Massachusetts Consortium for Pathogen ReadinessNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jesse Fajnzylber James Regan Kendyll Coxen Heather Corry Colline Wong Alexandra Rosenthal Daniel Worrall Francoise Giguel Alicja Piechocka-Trocha Caroline Atyeo Stephanie Fischinger Andrew Chan Keith T. Flaherty Kathryn Hall Michael Dougan Edward T. Ryan Elizabeth Gillespie Rida Chishti Yijia Li Nikolaus Jilg Dusan Hanidziar Rebecca M. Baron Lindsey Baden Athe M. Tsibris Katrina A. Armstrong Daniel R. Kuritzkes Galit Alter Bruce D. Walker Xu Yu Jonathan Z. Li The Massachusetts Consortium for Pathogen Readiness SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| description |
In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death. |
| format |
article |
| author |
Jesse Fajnzylber James Regan Kendyll Coxen Heather Corry Colline Wong Alexandra Rosenthal Daniel Worrall Francoise Giguel Alicja Piechocka-Trocha Caroline Atyeo Stephanie Fischinger Andrew Chan Keith T. Flaherty Kathryn Hall Michael Dougan Edward T. Ryan Elizabeth Gillespie Rida Chishti Yijia Li Nikolaus Jilg Dusan Hanidziar Rebecca M. Baron Lindsey Baden Athe M. Tsibris Katrina A. Armstrong Daniel R. Kuritzkes Galit Alter Bruce D. Walker Xu Yu Jonathan Z. Li The Massachusetts Consortium for Pathogen Readiness |
| author_facet |
Jesse Fajnzylber James Regan Kendyll Coxen Heather Corry Colline Wong Alexandra Rosenthal Daniel Worrall Francoise Giguel Alicja Piechocka-Trocha Caroline Atyeo Stephanie Fischinger Andrew Chan Keith T. Flaherty Kathryn Hall Michael Dougan Edward T. Ryan Elizabeth Gillespie Rida Chishti Yijia Li Nikolaus Jilg Dusan Hanidziar Rebecca M. Baron Lindsey Baden Athe M. Tsibris Katrina A. Armstrong Daniel R. Kuritzkes Galit Alter Bruce D. Walker Xu Yu Jonathan Z. Li The Massachusetts Consortium for Pathogen Readiness |
| author_sort |
Jesse Fajnzylber |
| title |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_short |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_full |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_fullStr |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_full_unstemmed |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_sort |
sars-cov-2 viral load is associated with increased disease severity and mortality |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/d3b04d9a629f44488b9f26c98ed75ef0 |
| work_keys_str_mv |
AT jessefajnzylber sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT jamesregan sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT kendyllcoxen sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT heathercorry sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT collinewong sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT alexandrarosenthal sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT danielworrall sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT francoisegiguel sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT alicjapiechockatrocha sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT carolineatyeo sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT stephaniefischinger sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT andrewchan sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT keithtflaherty sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT kathrynhall sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT michaeldougan sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT edwardtryan sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT elizabethgillespie sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT ridachishti sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT yijiali sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT nikolausjilg sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT dusanhanidziar sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT rebeccambaron sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT lindseybaden sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT athemtsibris sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT katrinaaarmstrong sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT danielrkuritzkes sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT galitalter sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT brucedwalker sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT xuyu sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT jonathanzli sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality AT themassachusettsconsortiumforpathogenreadiness sarscov2viralloadisassociatedwithincreaseddiseaseseverityandmortality |
| _version_ |
1718389598022795264 |