Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice

Schumannianthus dichotomus (Roxb.) is a perennial shrub from Marantaceace family. In traditional medicine, rhizome of the plant is used in fever and stem is used in earache. We aimed to substantiate these therapeutic claims by examining their effects in mice model. Antinociceptive effect was evaluat...

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Autores principales:	Mohammad Anwarul Basher, Md. Rafiul Hoque, Roni Roy, Sazzad Hosen, Irin Karim, Tanaya Bhowmik, Afroza Akter
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2020
Materias:	schumannianthus dichotomus, swiss albino mice, sex dimorphism, antinociceptive, antipyretic Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d3b20b8998e5442b8bc560732762a7f3
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spelling	oai:doaj.org-article:d3b20b8998e5442b8bc560732762a7f32021-11-15T06:08:47ZSex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice2338-94272338-948610.22146/ijp.602https://doaj.org/article/d3b20b8998e5442b8bc560732762a7f32020-12-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/602https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Schumannianthus dichotomus (Roxb.) is a perennial shrub from Marantaceace family. In traditional medicine, rhizome of the plant is used in fever and stem is used in earache. We aimed to substantiate these therapeutic claims by examining their effects in mice model. Antinociceptive effect was evaluated by three pain models and antipyretic effect was tested by yeast induced hyperthermia experiment. Influence of mice sexes on these pharmacological effects was examined by performing experiments separately on male and female mice. Quantitative analyses of total phenols and flavonoids were performed. Antinociceptive effects showed striking sex dimorphism. In hind paw licking test, male mice showed significant reductions in licking in both phases for both rhizome and stem extracts while significant effect was observed only in late phase in female mice. In writhing test, antinociception is more profound in male than in female. In hot plate test, stem was more effective than rhizome in male mice while female mice produced little effect for both extracts. Antipyretic experiment also showed varied effect in male and female mice; both extracts showed significant decrease in body temperatures. Rhizome showed greater effect in female mice while stem was more effective in male mice. Total phenol and flavonoid in rhizome were found 103.08 mg GAE (gallic acid equivalent) and 9.07mg QE (quercetin equivalent) respectively while in stem, these were 43.39mg GAE and 20.93 QE. Antinociceptive and antipyretic effects of rhizome and stem extracts endorsed the traditional uses of S. dichotomus. Also, differential effects based on mouse sex indicate the prerequisite of both male and female mice model in therapeutic evaluations of plant extract.Mohammad Anwarul BasherMd. Rafiul HoqueRoni RoySazzad HosenIrin KarimTanaya BhowmikAfroza AkterUniversitas Gadjah Madaarticleschumannianthus dichotomus, swiss albino mice, sex dimorphism, antinociceptive, antipyreticPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 323–334-323–334 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	schumannianthus dichotomus, swiss albino mice, sex dimorphism, antinociceptive, antipyretic Pharmacy and materia medica RS1-441
spellingShingle	schumannianthus dichotomus, swiss albino mice, sex dimorphism, antinociceptive, antipyretic Pharmacy and materia medica RS1-441 Mohammad Anwarul Basher Md. Rafiul Hoque Roni Roy Sazzad Hosen Irin Karim Tanaya Bhowmik Afroza Akter Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice
description	Schumannianthus dichotomus (Roxb.) is a perennial shrub from Marantaceace family. In traditional medicine, rhizome of the plant is used in fever and stem is used in earache. We aimed to substantiate these therapeutic claims by examining their effects in mice model. Antinociceptive effect was evaluated by three pain models and antipyretic effect was tested by yeast induced hyperthermia experiment. Influence of mice sexes on these pharmacological effects was examined by performing experiments separately on male and female mice. Quantitative analyses of total phenols and flavonoids were performed. Antinociceptive effects showed striking sex dimorphism. In hind paw licking test, male mice showed significant reductions in licking in both phases for both rhizome and stem extracts while significant effect was observed only in late phase in female mice. In writhing test, antinociception is more profound in male than in female. In hot plate test, stem was more effective than rhizome in male mice while female mice produced little effect for both extracts. Antipyretic experiment also showed varied effect in male and female mice; both extracts showed significant decrease in body temperatures. Rhizome showed greater effect in female mice while stem was more effective in male mice. Total phenol and flavonoid in rhizome were found 103.08 mg GAE (gallic acid equivalent) and 9.07mg QE (quercetin equivalent) respectively while in stem, these were 43.39mg GAE and 20.93 QE. Antinociceptive and antipyretic effects of rhizome and stem extracts endorsed the traditional uses of S. dichotomus. Also, differential effects based on mouse sex indicate the prerequisite of both male and female mice model in therapeutic evaluations of plant extract.
format	article
author	Mohammad Anwarul Basher Md. Rafiul Hoque Roni Roy Sazzad Hosen Irin Karim Tanaya Bhowmik Afroza Akter
author_facet	Mohammad Anwarul Basher Md. Rafiul Hoque Roni Roy Sazzad Hosen Irin Karim Tanaya Bhowmik Afroza Akter
author_sort	Mohammad Anwarul Basher
title	Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice
title_short	Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice
title_full	Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice
title_fullStr	Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice
title_full_unstemmed	Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice
title_sort	sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of schumannianthus dichotomus roxb. in male and female mice
publisher	Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/d3b20b8998e5442b8bc560732762a7f3
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Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice

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