H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

Mechanisms underlying gene repression and silencers remain poorly understood. Here the authors investigate the role of H3K27me3-rich regions in the genome, as defined from clusters of H3K27me3 peaks, in regulating gene expression via looping.

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Autores principales:	Yichao Cai, Ying Zhang, Yan Ping Loh, Jia Qi Tng, Mei Chee Lim, Zhendong Cao, Anandhkumar Raju, Erez Lieberman Aiden, Shang Li, Lakshmanan Manikandan, Vinay Tergaonkar, Greg Tucker-Kellogg, Melissa Jane Fullwood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d3b2681ce73046bd90d6e3a3c6cb6762
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spelling	oai:doaj.org-article:d3b2681ce73046bd90d6e3a3c6cb67622021-12-02T13:57:31ZH3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions10.1038/s41467-021-20940-y2041-1723https://doaj.org/article/d3b2681ce73046bd90d6e3a3c6cb67622021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20940-yhttps://doaj.org/toc/2041-1723Mechanisms underlying gene repression and silencers remain poorly understood. Here the authors investigate the role of H3K27me3-rich regions in the genome, as defined from clusters of H3K27me3 peaks, in regulating gene expression via looping.Yichao CaiYing ZhangYan Ping LohJia Qi TngMei Chee LimZhendong CaoAnandhkumar RajuErez Lieberman AidenShang LiLakshmanan ManikandanVinay TergaonkarGreg Tucker-KelloggMelissa Jane FullwoodNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yichao Cai Ying Zhang Yan Ping Loh Jia Qi Tng Mei Chee Lim Zhendong Cao Anandhkumar Raju Erez Lieberman Aiden Shang Li Lakshmanan Manikandan Vinay Tergaonkar Greg Tucker-Kellogg Melissa Jane Fullwood H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
description	Mechanisms underlying gene repression and silencers remain poorly understood. Here the authors investigate the role of H3K27me3-rich regions in the genome, as defined from clusters of H3K27me3 peaks, in regulating gene expression via looping.
format	article
author	Yichao Cai Ying Zhang Yan Ping Loh Jia Qi Tng Mei Chee Lim Zhendong Cao Anandhkumar Raju Erez Lieberman Aiden Shang Li Lakshmanan Manikandan Vinay Tergaonkar Greg Tucker-Kellogg Melissa Jane Fullwood
author_facet	Yichao Cai Ying Zhang Yan Ping Loh Jia Qi Tng Mei Chee Lim Zhendong Cao Anandhkumar Raju Erez Lieberman Aiden Shang Li Lakshmanan Manikandan Vinay Tergaonkar Greg Tucker-Kellogg Melissa Jane Fullwood
author_sort	Yichao Cai
title	H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
title_short	H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
title_full	H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
title_fullStr	H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
title_full_unstemmed	H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
title_sort	h3k27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d3b2681ce73046bd90d6e3a3c6cb6762
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H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

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