Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease

Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease

Traditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and protect the leaky gut barrier in inflammatory bowel dis...

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Autores principales: Debashis Sahoo, Lee Swanson, Ibrahim M. Sayed, Gajanan D. Katkar, Stella-Rita Ibeawuchi, Yash Mittal, Rama F. Pranadinata, Courtney Tindle, Mackenzie Fuller, Dominik L. Stec, John T. Chang, William J. Sandborn, Soumita Das, Pradipta Ghosh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/d3b3157a040445e7931fa319037c2287
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Sumario:Traditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and protect the leaky gut barrier in inflammatory bowel disease.

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