Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens

Abstract Background Eggshell is a bio-ceramic material comprising columnar calcite (CaCO3) crystals and organic proteinaceous matrix. The size, shape and orientation of the CaCO3 crystals influence the microstructural properties of chicken eggshells. However, the genetic architecture underlying eggs...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Quanlin Li, Zhongyi Duan, Congjiao Sun, Jiangxia Zheng, Guiyun Xu, Ning Yang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chicken Eggshell Crystal structure X-ray diffraction GWAS Biotechnology TP248.13-248.65 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/d3babd1d368c4ad580bd01436b8eb406
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d3babd1d368c4ad580bd01436b8eb406
record_format	dspace
spelling	oai:doaj.org-article:d3babd1d368c4ad580bd01436b8eb4062021-11-08T10:57:35ZGenetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens10.1186/s12864-021-08103-11471-2164https://doaj.org/article/d3babd1d368c4ad580bd01436b8eb4062021-11-01T00:00:00Zhttps://doi.org/10.1186/s12864-021-08103-1https://doaj.org/toc/1471-2164Abstract Background Eggshell is a bio-ceramic material comprising columnar calcite (CaCO3) crystals and organic proteinaceous matrix. The size, shape and orientation of the CaCO3 crystals influence the microstructural properties of chicken eggshells. However, the genetic architecture underlying eggshell crystal polymorphism remains to be elucidated. Results The integral intensity of the nine major diffraction peaks, total integral intensity and degree of orientation of the crystals were measured followed by a genome-wide association study in 839 F2 hens. The results showed that the total integral intensity was positively correlated with the eggshell strength, eggshell thickness, eggshell weight, mammillary layer thickness and effective layer thickness. The SNP-based heritabilities of total integral intensity and degree of orientation were 0.23 and 0.06, respectively. The 621 SNPs located in the range from 55.6 to 69.1 Mb in GGA1 were significantly associated with TA. PLCZ1, ABCC9, ITPR2, KCNJ8, CACNA1C and IAPP, which are involved in the biological process of regulating cytosolic calcium ion concentration, can be suggested as key genes regulating the total integral intensity. Conclusions The findings greatly advance the understanding of the genetic basis underlying the crystal ultrastructure of eggshell quality and thus will have practical significance in breeding programs for improving eggshell quality.Quanlin LiZhongyi DuanCongjiao SunJiangxia ZhengGuiyun XuNing YangBMCarticleChickenEggshellCrystal structureX-ray diffractionGWASBiotechnologyTP248.13-248.65GeneticsQH426-470ENBMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chicken Eggshell Crystal structure X-ray diffraction GWAS Biotechnology TP248.13-248.65 Genetics QH426-470
spellingShingle	Chicken Eggshell Crystal structure X-ray diffraction GWAS Biotechnology TP248.13-248.65 Genetics QH426-470 Quanlin Li Zhongyi Duan Congjiao Sun Jiangxia Zheng Guiyun Xu Ning Yang Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens
description	Abstract Background Eggshell is a bio-ceramic material comprising columnar calcite (CaCO3) crystals and organic proteinaceous matrix. The size, shape and orientation of the CaCO3 crystals influence the microstructural properties of chicken eggshells. However, the genetic architecture underlying eggshell crystal polymorphism remains to be elucidated. Results The integral intensity of the nine major diffraction peaks, total integral intensity and degree of orientation of the crystals were measured followed by a genome-wide association study in 839 F2 hens. The results showed that the total integral intensity was positively correlated with the eggshell strength, eggshell thickness, eggshell weight, mammillary layer thickness and effective layer thickness. The SNP-based heritabilities of total integral intensity and degree of orientation were 0.23 and 0.06, respectively. The 621 SNPs located in the range from 55.6 to 69.1 Mb in GGA1 were significantly associated with TA. PLCZ1, ABCC9, ITPR2, KCNJ8, CACNA1C and IAPP, which are involved in the biological process of regulating cytosolic calcium ion concentration, can be suggested as key genes regulating the total integral intensity. Conclusions The findings greatly advance the understanding of the genetic basis underlying the crystal ultrastructure of eggshell quality and thus will have practical significance in breeding programs for improving eggshell quality.
format	article
author	Quanlin Li Zhongyi Duan Congjiao Sun Jiangxia Zheng Guiyun Xu Ning Yang
author_facet	Quanlin Li Zhongyi Duan Congjiao Sun Jiangxia Zheng Guiyun Xu Ning Yang
author_sort	Quanlin Li
title	Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens
title_short	Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens
title_full	Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens
title_fullStr	Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens
title_full_unstemmed	Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens
title_sort	genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d3babd1d368c4ad580bd01436b8eb406
work_keys_str_mv	AT quanlinli geneticvariationsfortheeggshellcrystalstructurerevealedbygenomewideassociationstudyinchickens AT zhongyiduan geneticvariationsfortheeggshellcrystalstructurerevealedbygenomewideassociationstudyinchickens AT congjiaosun geneticvariationsfortheeggshellcrystalstructurerevealedbygenomewideassociationstudyinchickens AT jiangxiazheng geneticvariationsfortheeggshellcrystalstructurerevealedbygenomewideassociationstudyinchickens AT guiyunxu geneticvariationsfortheeggshellcrystalstructurerevealedbygenomewideassociationstudyinchickens AT ningyang geneticvariationsfortheeggshellcrystalstructurerevealedbygenomewideassociationstudyinchickens
_version_	1718442473401876480

Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens

Ejemplares similares