Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma
BackgroundEarly diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which could be used as a biomarker for predicting PTC...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:d3bb3ab1617645b8a1c2b1c7a393d5582021-11-05T16:29:14ZComplement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma1664-239210.3389/fendo.2021.737638https://doaj.org/article/d3bb3ab1617645b8a1c2b1c7a393d5582021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.737638/fullhttps://doaj.org/toc/1664-2392BackgroundEarly diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which could be used as a biomarker for predicting PTC.MethodsSerum samples were collected from 29 PTC patients and 29 nodular goiter (NG) patients. Five PTC serum samples and five NG serum samples were selected for proteome profiles by proteomics. Eight proteins in PTC and NG serum samples were selected for confirmation by enzyme-linked immunosorbent assay analysis. Receiver operating characteristic curves was used to evaluate the diagnostic value of potential biomarkers.ResultsComplement C4-A (C4A) and plasminogen (PLG) were significantly lower in serum samples of PTC patients compared with NG patients. C4A was observed to have excellent diagnostic accuracy for PTC, with a sensitivity of 91.67% and specificity of 83.33%. The diagnostic value of PLG for PTC was demonstrated by a sensitivity at 87.50% and specificity at 75.00%. The AUC for C4A and PLG was 0.97 ± 0.02 and 0.89 ± 0.05.ConclusionC4A and PLG appeared to be excellent potential biomarkers for the prediction of PTC.Yichao WangYichao WangShengliang ZhouShengliang ZhouShengliang ZhouDun WangDun WangDun WangTao WeiTao WeiJingqiang ZhuJingqiang ZhuZhihui LiFrontiers Media S.A.articlepapillary thyroid carcinomabiomarkercomplement C4-AplasminogenpredictionDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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papillary thyroid carcinoma biomarker complement C4-A plasminogen prediction Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
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papillary thyroid carcinoma biomarker complement C4-A plasminogen prediction Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yichao Wang Yichao Wang Shengliang Zhou Shengliang Zhou Shengliang Zhou Dun Wang Dun Wang Dun Wang Tao Wei Tao Wei Jingqiang Zhu Jingqiang Zhu Zhihui Li Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma |
| description |
BackgroundEarly diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which could be used as a biomarker for predicting PTC.MethodsSerum samples were collected from 29 PTC patients and 29 nodular goiter (NG) patients. Five PTC serum samples and five NG serum samples were selected for proteome profiles by proteomics. Eight proteins in PTC and NG serum samples were selected for confirmation by enzyme-linked immunosorbent assay analysis. Receiver operating characteristic curves was used to evaluate the diagnostic value of potential biomarkers.ResultsComplement C4-A (C4A) and plasminogen (PLG) were significantly lower in serum samples of PTC patients compared with NG patients. C4A was observed to have excellent diagnostic accuracy for PTC, with a sensitivity of 91.67% and specificity of 83.33%. The diagnostic value of PLG for PTC was demonstrated by a sensitivity at 87.50% and specificity at 75.00%. The AUC for C4A and PLG was 0.97 ± 0.02 and 0.89 ± 0.05.ConclusionC4A and PLG appeared to be excellent potential biomarkers for the prediction of PTC. |
| format |
article |
| author |
Yichao Wang Yichao Wang Shengliang Zhou Shengliang Zhou Shengliang Zhou Dun Wang Dun Wang Dun Wang Tao Wei Tao Wei Jingqiang Zhu Jingqiang Zhu Zhihui Li |
| author_facet |
Yichao Wang Yichao Wang Shengliang Zhou Shengliang Zhou Shengliang Zhou Dun Wang Dun Wang Dun Wang Tao Wei Tao Wei Jingqiang Zhu Jingqiang Zhu Zhihui Li |
| author_sort |
Yichao Wang |
| title |
Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma |
| title_short |
Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma |
| title_full |
Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma |
| title_fullStr |
Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma |
| title_full_unstemmed |
Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma |
| title_sort |
complement c4-a and plasminogen as potential biomarkers for prediction of papillary thyroid carcinoma |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/d3bb3ab1617645b8a1c2b1c7a393d558 |
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