Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage

Translesion synthesis (TLS) enables cells to tolerate damaged DNA encountered during replication. Here the authors use super-resolution photoactivation localization microscopy to reveal a lesion type dependent mechanism of recruitment of the TLS polymerase Pol IV following DNA damage.

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Detalles Bibliográficos
Autores principales:	Elizabeth S. Thrall, James E. Kath, Seungwoo Chang, Joseph J. Loparo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d3bdcb38b59846ff94dc46e555e13faf
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spelling	oai:doaj.org-article:d3bdcb38b59846ff94dc46e555e13faf2021-12-02T14:42:06ZSingle-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage10.1038/s41467-017-02333-22041-1723https://doaj.org/article/d3bdcb38b59846ff94dc46e555e13faf2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02333-2https://doaj.org/toc/2041-1723Translesion synthesis (TLS) enables cells to tolerate damaged DNA encountered during replication. Here the authors use super-resolution photoactivation localization microscopy to reveal a lesion type dependent mechanism of recruitment of the TLS polymerase Pol IV following DNA damage.Elizabeth S. ThrallJames E. KathSeungwoo ChangJoseph J. LoparoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth S. Thrall James E. Kath Seungwoo Chang Joseph J. Loparo Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
description	Translesion synthesis (TLS) enables cells to tolerate damaged DNA encountered during replication. Here the authors use super-resolution photoactivation localization microscopy to reveal a lesion type dependent mechanism of recruitment of the TLS polymerase Pol IV following DNA damage.
format	article
author	Elizabeth S. Thrall James E. Kath Seungwoo Chang Joseph J. Loparo
author_facet	Elizabeth S. Thrall James E. Kath Seungwoo Chang Joseph J. Loparo
author_sort	Elizabeth S. Thrall
title	Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
title_short	Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
title_full	Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
title_fullStr	Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
title_full_unstemmed	Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
title_sort	single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after dna damage
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d3bdcb38b59846ff94dc46e555e13faf
work_keys_str_mv	AT elizabethsthrall singlemoleculeimagingrevealsmultiplepathwaysfortherecruitmentoftranslesionpolymerasesafterdnadamage AT jamesekath singlemoleculeimagingrevealsmultiplepathwaysfortherecruitmentoftranslesionpolymerasesafterdnadamage AT seungwoochang singlemoleculeimagingrevealsmultiplepathwaysfortherecruitmentoftranslesionpolymerasesafterdnadamage AT josephjloparo singlemoleculeimagingrevealsmultiplepathwaysfortherecruitmentoftranslesionpolymerasesafterdnadamage
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Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage

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