Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage

Translesion synthesis (TLS) enables cells to tolerate damaged DNA encountered during replication. Here the authors use super-resolution photoactivation localization microscopy to reveal a lesion type dependent mechanism of recruitment of the TLS polymerase Pol IV following DNA damage.

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Autores principales: Elizabeth S. Thrall, James E. Kath, Seungwoo Chang, Joseph J. Loparo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d3bdcb38b59846ff94dc46e555e13faf
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