RADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 60

BACKGROUND AND OBJECTIVE: The main purpose of radiotherapy is exposing enough dose to tumoral volume and protecting the normal tissues around it. Tumor dose for each fraction in radiotherapy prescribes with tumoral tissue consideration. Since viral diseases can affect cell radiosensitivity, this stu...

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Autores principales:	F Seif, MR Baiatiani, MJ Tahmasebi Birgani, A Sohrabi, F Hosseini
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	radiosensitivity hela cells polio virus Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d3be01e31d084671a5c119500c958880
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spelling	oai:doaj.org-article:d3be01e31d084671a5c119500c9588802021-11-10T09:07:36ZRADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 601561-41072251-7170https://doaj.org/article/d3be01e31d084671a5c119500c9588802008-08-01T00:00:00Zhttp://jbums.org/article-1-2467-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: The main purpose of radiotherapy is exposing enough dose to tumoral volume and protecting the normal tissues around it. Tumor dose for each fraction in radiotherapy prescribes with tumoral tissue consideration. Since viral diseases can affect cell radiosensitivity, this study was done to evaluate the radiosensitivity of tumoral cell that infected with virus. METHODS: In this study the radiosensitivity of HeLa cell with and without the viral agent of polio disease was obtained and compared after gamma radiation of cobalt 60. Different polio vaccine was used to infect cell with polio virus. Finally calculated the percentage of plating efficiency and relative survival at radiated and control cells with colonies countering. FINDINGS: Results implicate that cell death increases up to 20-30% for contaminating with low concentrations of polio virus, 30-40% for moderate concentrations and 70-90% for high concentrations after 2Gy irradiation by cobalt 60. CONCLUSION: Results of this study showed that existing of viral disease in tumoral region can increase radiosensitivity of tumoral cells. Therefore non cancer disease in region under irradiation should be noticed to prescribing dose fraction in radiotherapy of cancers.F SeifMR Baiatiani,MJ Tahmasebi Birgani,A SohrabiF HosseiniBabol University of Medical Sciencesarticleradiosensitivityhela cellspolio virusMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 3, Pp 25-29 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	radiosensitivity hela cells polio virus Medicine R Medicine (General) R5-920
spellingShingle	radiosensitivity hela cells polio virus Medicine R Medicine (General) R5-920 F Seif MR Baiatiani, MJ Tahmasebi Birgani, A Sohrabi F Hosseini RADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 60
description	BACKGROUND AND OBJECTIVE: The main purpose of radiotherapy is exposing enough dose to tumoral volume and protecting the normal tissues around it. Tumor dose for each fraction in radiotherapy prescribes with tumoral tissue consideration. Since viral diseases can affect cell radiosensitivity, this study was done to evaluate the radiosensitivity of tumoral cell that infected with virus. METHODS: In this study the radiosensitivity of HeLa cell with and without the viral agent of polio disease was obtained and compared after gamma radiation of cobalt 60. Different polio vaccine was used to infect cell with polio virus. Finally calculated the percentage of plating efficiency and relative survival at radiated and control cells with colonies countering. FINDINGS: Results implicate that cell death increases up to 20-30% for contaminating with low concentrations of polio virus, 30-40% for moderate concentrations and 70-90% for high concentrations after 2Gy irradiation by cobalt 60. CONCLUSION: Results of this study showed that existing of viral disease in tumoral region can increase radiosensitivity of tumoral cells. Therefore non cancer disease in region under irradiation should be noticed to prescribing dose fraction in radiotherapy of cancers.
format	article
author	F Seif MR Baiatiani, MJ Tahmasebi Birgani, A Sohrabi F Hosseini
author_facet	F Seif MR Baiatiani, MJ Tahmasebi Birgani, A Sohrabi F Hosseini
author_sort	F Seif
title	RADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 60
title_short	RADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 60
title_full	RADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 60
title_fullStr	RADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 60
title_full_unstemmed	RADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 60
title_sort	radiosensitivity of hela cells infected with polio virus irradiated by co 60
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/d3be01e31d084671a5c119500c958880
work_keys_str_mv	AT fseif radiosensitivityofhelacellsinfectedwithpoliovirusirradiatedbyco60 AT mrbaiatiani radiosensitivityofhelacellsinfectedwithpoliovirusirradiatedbyco60 AT mjtahmasebibirgani radiosensitivityofhelacellsinfectedwithpoliovirusirradiatedbyco60 AT asohrabi radiosensitivityofhelacellsinfectedwithpoliovirusirradiatedbyco60 AT fhosseini radiosensitivityofhelacellsinfectedwithpoliovirusirradiatedbyco60
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RADIOSENSITIVITY OF HELA CELLS INFECTED WITH POLIO VIRUS IRRADIATED BY CO 60

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