The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes

Background. The main aims of the conservative treatment of metabolic obesity (MО) are weight loss and the prevention of type 2 diabetes. Incretin-based drugs are considered to be effective and safe and stimulate insulin secretion via the β-cells of the pancreas, and are widely used to restore impair...

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Autores principales:	Elena Vital'evna Kirienkova, Mariia Aleksandrovna Vasilenko, Pavel Anatol'evich Zatolokin, Nataliya Ivanovna Mironyuk, Dar'ya Aleksandrovna Skuratovskaia, Larisa Sergeevna Litvinova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	сахарный диабет 2 типа инсулинорезистентность gip glp-1 бариатрическая хирургия Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/d3be2bef7b97498a863648c5dc8d11c5
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spelling	oai:doaj.org-article:d3be2bef7b97498a863648c5dc8d11c52021-11-14T09:00:20ZThe postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes2072-03512072-037810.14341/DM7149https://doaj.org/article/d3be2bef7b97498a863648c5dc8d11c52015-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7149https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background. The main aims of the conservative treatment of metabolic obesity (MО) are weight loss and the prevention of type 2 diabetes. Incretin-based drugs are considered to be effective and safe and stimulate insulin secretion via the β-cells of the pancreas, and are widely used to restore impaired glucose tolerance. Bariatric surgery not only significantly reduces BMI but also normalises carbohydrate metabolism in patients with MО over a short period after the operation by increasing the secretion of endogenous incretins.Aim. To investigate hormone secretion in the gastroduodenal zone in patients with MО after Roux-en-Y gastric bypass before and after a test meal.Material and methods. We studied the plasma levels of insulin, C-peptide, glucagon, ghrelin and incretins (GIP and GLP-1) using flow fluorometry in 28 patients with MO (12 males and 16 females aged 29–63 years). Patients were divided into two groups: those who did not undergo gastric bypass surgeries and those after treatment (18 months).Results. We found a postprandial increase in the plasma GIP levels with respect to the baseline values in all subject groups, regardless of whether or not they had type 2 diabetes. A analysis of the levels of postprandial GLP-1 secretion revealed the existence of multidirectional dynamics of this indicator regardless of the presence of type 2 diabetes: an increase, decrease, or no difference in GLP-1 secretion was found compared to the measurements on an empty stomach.Conclusions. The postprandial GIP levels increased compared with baseline levels in all groups. The dynamics of the changes in the postprandial GLP-1 levels were multidirectional in patients with MО regardless of the presence of impaired glucose tolerance after Roux-en-Y gastric bypass. A positive correlation was observed between the plasma ghrelin levels and glucagon in all groups.Elena Vital'evna KirienkovaMariia Aleksandrovna VasilenkoPavel Anatol'evich ZatolokinNataliya Ivanovna MironyukDar'ya Aleksandrovna SkuratovskaiaLarisa Sergeevna LitvinovaEndocrinology Research Centrearticleсахарный диабет 2 типаинсулинорезистентностьgipglp-1бариатрическая хирургияNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 4, Pp 22-27 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	сахарный диабет 2 типа инсулинорезистентность gip glp-1 бариатрическая хирургия Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	сахарный диабет 2 типа инсулинорезистентность gip glp-1 бариатрическая хирургия Nutritional diseases. Deficiency diseases RC620-627 Elena Vital'evna Kirienkova Mariia Aleksandrovna Vasilenko Pavel Anatol'evich Zatolokin Nataliya Ivanovna Mironyuk Dar'ya Aleksandrovna Skuratovskaia Larisa Sergeevna Litvinova The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes
description	Background. The main aims of the conservative treatment of metabolic obesity (MО) are weight loss and the prevention of type 2 diabetes. Incretin-based drugs are considered to be effective and safe and stimulate insulin secretion via the β-cells of the pancreas, and are widely used to restore impaired glucose tolerance. Bariatric surgery not only significantly reduces BMI but also normalises carbohydrate metabolism in patients with MО over a short period after the operation by increasing the secretion of endogenous incretins.Aim. To investigate hormone secretion in the gastroduodenal zone in patients with MО after Roux-en-Y gastric bypass before and after a test meal.Material and methods. We studied the plasma levels of insulin, C-peptide, glucagon, ghrelin and incretins (GIP and GLP-1) using flow fluorometry in 28 patients with MO (12 males and 16 females aged 29–63 years). Patients were divided into two groups: those who did not undergo gastric bypass surgeries and those after treatment (18 months).Results. We found a postprandial increase in the plasma GIP levels with respect to the baseline values in all subject groups, regardless of whether or not they had type 2 diabetes. A analysis of the levels of postprandial GLP-1 secretion revealed the existence of multidirectional dynamics of this indicator regardless of the presence of type 2 diabetes: an increase, decrease, or no difference in GLP-1 secretion was found compared to the measurements on an empty stomach.Conclusions. The postprandial GIP levels increased compared with baseline levels in all groups. The dynamics of the changes in the postprandial GLP-1 levels were multidirectional in patients with MО regardless of the presence of impaired glucose tolerance after Roux-en-Y gastric bypass. A positive correlation was observed between the plasma ghrelin levels and glucagon in all groups.
format	article
author	Elena Vital'evna Kirienkova Mariia Aleksandrovna Vasilenko Pavel Anatol'evich Zatolokin Nataliya Ivanovna Mironyuk Dar'ya Aleksandrovna Skuratovskaia Larisa Sergeevna Litvinova
author_facet	Elena Vital'evna Kirienkova Mariia Aleksandrovna Vasilenko Pavel Anatol'evich Zatolokin Nataliya Ivanovna Mironyuk Dar'ya Aleksandrovna Skuratovskaia Larisa Sergeevna Litvinova
author_sort	Elena Vital'evna Kirienkova
title	The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes
title_short	The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes
title_full	The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes
title_fullStr	The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes
title_full_unstemmed	The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes
title_sort	postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/d3be2bef7b97498a863648c5dc8d11c5
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The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes

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