EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy

Resistance to anti-HER2 therapies in breast cancer remains a significant clinical challenge. Here, the authors demonstrate that EZH2 regulates response to HER2-targeting therapies in breast cancer, in part, by modulating the expression of PPP2R2B.

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Autores principales:	Yi Bao, Gokce Oguz, Wee Chyan Lee, Puay Leng Lee, Kakaly Ghosh, Jiayao Li, Panpan Wang, Peter E. Lobie, Sidse Ehmsen, Henrik J. Ditzel, Andrea Wong, Ern Yu Tan, Soo Chin Lee, Qiang Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d3c09063233a46f7b4d0dbd7cf8055f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d3c09063233a46f7b4d0dbd7cf8055f02021-12-02T15:39:23ZEZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy10.1038/s41467-020-19704-x2041-1723https://doaj.org/article/d3c09063233a46f7b4d0dbd7cf8055f02020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19704-xhttps://doaj.org/toc/2041-1723Resistance to anti-HER2 therapies in breast cancer remains a significant clinical challenge. Here, the authors demonstrate that EZH2 regulates response to HER2-targeting therapies in breast cancer, in part, by modulating the expression of PPP2R2B.Yi BaoGokce OguzWee Chyan LeePuay Leng LeeKakaly GhoshJiayao LiPanpan WangPeter E. LobieSidse EhmsenHenrik J. DitzelAndrea WongErn Yu TanSoo Chin LeeQiang YuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Bao Gokce Oguz Wee Chyan Lee Puay Leng Lee Kakaly Ghosh Jiayao Li Panpan Wang Peter E. Lobie Sidse Ehmsen Henrik J. Ditzel Andrea Wong Ern Yu Tan Soo Chin Lee Qiang Yu EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
description	Resistance to anti-HER2 therapies in breast cancer remains a significant clinical challenge. Here, the authors demonstrate that EZH2 regulates response to HER2-targeting therapies in breast cancer, in part, by modulating the expression of PPP2R2B.
format	article
author	Yi Bao Gokce Oguz Wee Chyan Lee Puay Leng Lee Kakaly Ghosh Jiayao Li Panpan Wang Peter E. Lobie Sidse Ehmsen Henrik J. Ditzel Andrea Wong Ern Yu Tan Soo Chin Lee Qiang Yu
author_facet	Yi Bao Gokce Oguz Wee Chyan Lee Puay Leng Lee Kakaly Ghosh Jiayao Li Panpan Wang Peter E. Lobie Sidse Ehmsen Henrik J. Ditzel Andrea Wong Ern Yu Tan Soo Chin Lee Qiang Yu
author_sort	Yi Bao
title	EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
title_short	EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
title_full	EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
title_fullStr	EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
title_full_unstemmed	EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
title_sort	ezh2-mediated pp2a inactivation confers resistance to her2-targeted breast cancer therapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d3c09063233a46f7b4d0dbd7cf8055f0
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EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy

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