Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms

Long non-coding RNAs (lncRNAs) are the novel class of transcripts involved in transcriptional, post-transcriptional, translational, and post-translational regulation of physiology and the pathology of diseases. Studies have evidenced that the impairment of endothelium is a critical event in the path...

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Autores principales:	Ravichandran Jayasuriya, Kumar Ganesan, Baojun Xu, Kunka Mohanram Ramkumar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	LncRNA Chronic diseases Endothelial dysfunction Endothelial cell apoptosis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d3c2d6bb8593474391eea91a5ebabe4b
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spelling	oai:doaj.org-article:d3c2d6bb8593474391eea91a5ebabe4b2021-11-18T04:43:36ZEmerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms0753-332210.1016/j.biopha.2021.112421https://doaj.org/article/d3c2d6bb8593474391eea91a5ebabe4b2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012075https://doaj.org/toc/0753-3322Long non-coding RNAs (lncRNAs) are the novel class of transcripts involved in transcriptional, post-transcriptional, translational, and post-translational regulation of physiology and the pathology of diseases. Studies have evidenced that the impairment of endothelium is a critical event in the pathogenesis of atherosclerosis and its complications. Endothelial dysfunction is characterized by an imbalance in vasodilation and vasoconstriction, oxidative stress, proinflammatory factors, and nitric oxide bioavailability. Disruption of the endothelial barrier permeability, the first step in developing atherosclerotic lesions is a consequence of endothelial dysfunction. Though several factors interfere with the normal functioning of the endothelium, intrinsic epigenetic mechanisms governing endothelial function are regulated by lncRNAs and perturbations contribute to the pathogenesis of the disease. This review comprehensively addresses the biogenesis of lncRNA and molecular mechanisms underlying and regulation in endothelial function. An insight correlating lncRNAs and endothelial dysfunction-associated diseases can positively impact the development of novel biomarkers and therapeutic targets in endothelial dysfunction-associated diseases and treatment strategies.Ravichandran JayasuriyaKumar GanesanBaojun XuKunka Mohanram RamkumarElsevierarticleLncRNAChronic diseasesEndothelial dysfunctionEndothelial cell apoptosisTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112421- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	LncRNA Chronic diseases Endothelial dysfunction Endothelial cell apoptosis Therapeutics. Pharmacology RM1-950
spellingShingle	LncRNA Chronic diseases Endothelial dysfunction Endothelial cell apoptosis Therapeutics. Pharmacology RM1-950 Ravichandran Jayasuriya Kumar Ganesan Baojun Xu Kunka Mohanram Ramkumar Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms
description	Long non-coding RNAs (lncRNAs) are the novel class of transcripts involved in transcriptional, post-transcriptional, translational, and post-translational regulation of physiology and the pathology of diseases. Studies have evidenced that the impairment of endothelium is a critical event in the pathogenesis of atherosclerosis and its complications. Endothelial dysfunction is characterized by an imbalance in vasodilation and vasoconstriction, oxidative stress, proinflammatory factors, and nitric oxide bioavailability. Disruption of the endothelial barrier permeability, the first step in developing atherosclerotic lesions is a consequence of endothelial dysfunction. Though several factors interfere with the normal functioning of the endothelium, intrinsic epigenetic mechanisms governing endothelial function are regulated by lncRNAs and perturbations contribute to the pathogenesis of the disease. This review comprehensively addresses the biogenesis of lncRNA and molecular mechanisms underlying and regulation in endothelial function. An insight correlating lncRNAs and endothelial dysfunction-associated diseases can positively impact the development of novel biomarkers and therapeutic targets in endothelial dysfunction-associated diseases and treatment strategies.
format	article
author	Ravichandran Jayasuriya Kumar Ganesan Baojun Xu Kunka Mohanram Ramkumar
author_facet	Ravichandran Jayasuriya Kumar Ganesan Baojun Xu Kunka Mohanram Ramkumar
author_sort	Ravichandran Jayasuriya
title	Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms
title_short	Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms
title_full	Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms
title_fullStr	Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms
title_full_unstemmed	Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms
title_sort	emerging role of long non-coding rnas in endothelial dysfunction and their molecular mechanisms
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/d3c2d6bb8593474391eea91a5ebabe4b
work_keys_str_mv	AT ravichandranjayasuriya emergingroleoflongnoncodingrnasinendothelialdysfunctionandtheirmolecularmechanisms AT kumarganesan emergingroleoflongnoncodingrnasinendothelialdysfunctionandtheirmolecularmechanisms AT baojunxu emergingroleoflongnoncodingrnasinendothelialdysfunctionandtheirmolecularmechanisms AT kunkamohanramramkumar emergingroleoflongnoncodingrnasinendothelialdysfunctionandtheirmolecularmechanisms
_version_	1718425129644457984

Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms

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