Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona

Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona

Large-scale, unbiased proteomics studies of biological samples like plasma are constrained by the complexity of the proteome. Herein, the authors develop a highly parallel protein quantitation platform leveraging multi nanoparticle protein coronas for deep proteome sampling and biomarker discovery.

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Detalles Bibliográficos
Autores principales: John E. Blume, William C. Manning, Gregory Troiano, Daniel Hornburg, Michael Figa, Lyndal Hesterberg, Theodore L. Platt, Xiaoyan Zhao, Rea A. Cuaresma, Patrick A. Everley, Marwin Ko, Hope Liou, Max Mahoney, Shadi Ferdosi, Eltaher M. Elgierari, Craig Stolarczyk, Behzad Tangeysh, Hongwei Xia, Ryan Benz, Asim Siddiqui, Steven A. Carr, Philip Ma, Robert Langer, Vivek Farias, Omid C. Farokhzad
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/d3c8b28ba0034c5bb30a513f8c83660d
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Descripción
Sumario:Large-scale, unbiased proteomics studies of biological samples like plasma are constrained by the complexity of the proteome. Herein, the authors develop a highly parallel protein quantitation platform leveraging multi nanoparticle protein coronas for deep proteome sampling and biomarker discovery.

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