Genetic modification of primary human B cells to model high-grade lymphoma

Genetic modification of primary human B cells to model high-grade lymphoma

A dearth of adequate preclinical models to faithfully mimic diffuse large B-cell lymphoma has hampered the identification of driver genes. Here, the authors present a co-culture system that enables ex vivo expansion, viral transduction and transformation of primary human germinal center B cells.

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Detalles Bibliográficos
Autores principales: Rebecca Caeser, Miriam Di Re, Joanna A. Krupka, Jie Gao, Maribel Lara-Chica, João M. L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F. P. Runge, Philip A. Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J. P. Huntly, Annalisa Mupo, Rachael J. M. Bashford-Rogers, Daniel J. Hodson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d3c9bc11a5cc4cb39c1c847ddd0e75b2
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Descripción
Sumario:A dearth of adequate preclinical models to faithfully mimic diffuse large B-cell lymphoma has hampered the identification of driver genes. Here, the authors present a co-culture system that enables ex vivo expansion, viral transduction and transformation of primary human germinal center B cells.

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