Unlocked concanavalin A forms amyloid-like fibrils from coagulation of long-lived "crinkled" intermediates.

Understanding the early events during amyloid aggregation processes is crucial to single out the involved molecular mechanisms and for designing ad hoc strategies to prevent and reverse amyloidogenic disorders. Here, we show that, in conditions in which the protein is positively charged and its conf...

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Autores principales: Valeria Vetri, Maurizio Leone, Ludmilla A Morozova-Roche, Bente Vestergaard, Vito Foderà
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/d3d003ff8fde47428e19f17525147bf5
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