Treatment of UTIs Due to Klebsiella pneumoniae Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review

Background: K. pneumoniae is one of the bacteria most frequently causing health care-associated urinary tract infections, and increasingly incriminating Klebsiella pneumoniae carbapenemase producers (KPCp). Most infections caused by KPCp are nosocomial and might...

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Autores principales:	Caroline Chapelle, Benjamin Gaborit, Raphaëlle Dumont, Aurélien Dinh, Maxime Vallée
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	UTI KPC cefiderocol meropenem-vaborbactam ceftazidim-avibactam imipenem-relebactam Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d3d2cef3ac8a4b338454bfe53c7582b5
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spelling	oai:doaj.org-article:d3d2cef3ac8a4b338454bfe53c7582b52021-11-25T16:23:00ZTreatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review10.3390/antibiotics101113322079-6382https://doaj.org/article/d3d2cef3ac8a4b338454bfe53c7582b52021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1332https://doaj.org/toc/2079-6382Background: <i>K. pneumoniae</i> is one of the bacteria most frequently causing health care-associated urinary tract infections, and increasingly incriminating <i>Klebsiella pneumoniae</i> carbapenemase producers (KPCp). Most infections caused by KPCp are nosocomial and might cause serious issues, even leading to death in half of the reported cases. Our aim was to identify the best strategy, based on available scientific data, for the use of new antibiotic treatments to manage KPCp UTIs. Methods: this narrative review of the literature was performed according to the criteria of preferred reporting items for systematic review and meta-analyses statement (PRISMA) (2020). Results and Conclusions: KPCp-UTIs are a real challenge for physicians. While cefiderocol, meropenem-vaborbactam, ceftazidim-avibactam, and imipenem-relebactam represent a major step forward in the treatment of these UTIs, no guidelines are currently available, in view of choosing the most appropriate treatment, in each specific case.Caroline ChapelleBenjamin GaboritRaphaëlle DumontAurélien DinhMaxime ValléeMDPI AGarticleUTIKPCcefiderocolmeropenem-vaborbactamceftazidim-avibactamimipenem-relebactamTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1332, p 1332 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	UTI KPC cefiderocol meropenem-vaborbactam ceftazidim-avibactam imipenem-relebactam Therapeutics. Pharmacology RM1-950
spellingShingle	UTI KPC cefiderocol meropenem-vaborbactam ceftazidim-avibactam imipenem-relebactam Therapeutics. Pharmacology RM1-950 Caroline Chapelle Benjamin Gaborit Raphaëlle Dumont Aurélien Dinh Maxime Vallée Treatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review
description	Background: <i>K. pneumoniae</i> is one of the bacteria most frequently causing health care-associated urinary tract infections, and increasingly incriminating <i>Klebsiella pneumoniae</i> carbapenemase producers (KPCp). Most infections caused by KPCp are nosocomial and might cause serious issues, even leading to death in half of the reported cases. Our aim was to identify the best strategy, based on available scientific data, for the use of new antibiotic treatments to manage KPCp UTIs. Methods: this narrative review of the literature was performed according to the criteria of preferred reporting items for systematic review and meta-analyses statement (PRISMA) (2020). Results and Conclusions: KPCp-UTIs are a real challenge for physicians. While cefiderocol, meropenem-vaborbactam, ceftazidim-avibactam, and imipenem-relebactam represent a major step forward in the treatment of these UTIs, no guidelines are currently available, in view of choosing the most appropriate treatment, in each specific case.
format	article
author	Caroline Chapelle Benjamin Gaborit Raphaëlle Dumont Aurélien Dinh Maxime Vallée
author_facet	Caroline Chapelle Benjamin Gaborit Raphaëlle Dumont Aurélien Dinh Maxime Vallée
author_sort	Caroline Chapelle
title	Treatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review
title_short	Treatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review
title_full	Treatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review
title_fullStr	Treatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review
title_full_unstemmed	Treatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review
title_sort	treatment of utis due to <i>klebsiella pneumoniae</i> carbapenemase-producers: how to use new antibiotic drugs? a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d3d2cef3ac8a4b338454bfe53c7582b5
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Treatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review

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