Leukocyte Membrane Enzymes Play the Cell Adhesion Game

For a long time, proteins with enzymatic activity have not been usually considered to carry out other functions different from catalyzing chemical reactions within or outside the cell. Nevertheless, in the last few years several reports have uncovered the participation of numerous enzymes in other p...

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Autores principales:	Georgina I. López-Cortés, Laura Díaz-Alvarez, Enrique Ortega
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	moonlighting protein ectoenzyme cell adhesion signal transduction leukocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d3d686dad9fb4ef08b7253049f9655bb
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id	oai:doaj.org-article:d3d686dad9fb4ef08b7253049f9655bb
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spelling	oai:doaj.org-article:d3d686dad9fb4ef08b7253049f9655bb2021-11-30T12:40:23ZLeukocyte Membrane Enzymes Play the Cell Adhesion Game1664-322410.3389/fimmu.2021.742292https://doaj.org/article/d3d686dad9fb4ef08b7253049f9655bb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.742292/fullhttps://doaj.org/toc/1664-3224For a long time, proteins with enzymatic activity have not been usually considered to carry out other functions different from catalyzing chemical reactions within or outside the cell. Nevertheless, in the last few years several reports have uncovered the participation of numerous enzymes in other processes, placing them in the category of moonlighting proteins. Some moonlighting enzymes have been shown to participate in complex processes such as cell adhesion. Cell adhesion plays a physiological role in multiple processes: it enables cells to establish close contact with one another, allowing communication; it is a key step during cell migration; it is also involved in tightly binding neighboring cells in tissues, etc. Importantly, cell adhesion is also of great importance in pathophysiological scenarios like migration and metastasis establishment of cancer cells. Cell adhesion is strictly regulated through numerous switches: proteins, glycoproteins and other components of the cell membrane. Recently, several cell membrane enzymes have been reported to participate in distinct steps of the cell adhesion process. Here, we review a variety of examples of membrane bound enzymes participating in adhesion of immune cells.Georgina I. López-CortésLaura Díaz-AlvarezEnrique OrtegaFrontiers Media S.A.articlemoonlighting proteinectoenzymecell adhesionsignal transductionleukocytesImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	moonlighting protein ectoenzyme cell adhesion signal transduction leukocytes Immunologic diseases. Allergy RC581-607
spellingShingle	moonlighting protein ectoenzyme cell adhesion signal transduction leukocytes Immunologic diseases. Allergy RC581-607 Georgina I. López-Cortés Laura Díaz-Alvarez Enrique Ortega Leukocyte Membrane Enzymes Play the Cell Adhesion Game
description	For a long time, proteins with enzymatic activity have not been usually considered to carry out other functions different from catalyzing chemical reactions within or outside the cell. Nevertheless, in the last few years several reports have uncovered the participation of numerous enzymes in other processes, placing them in the category of moonlighting proteins. Some moonlighting enzymes have been shown to participate in complex processes such as cell adhesion. Cell adhesion plays a physiological role in multiple processes: it enables cells to establish close contact with one another, allowing communication; it is a key step during cell migration; it is also involved in tightly binding neighboring cells in tissues, etc. Importantly, cell adhesion is also of great importance in pathophysiological scenarios like migration and metastasis establishment of cancer cells. Cell adhesion is strictly regulated through numerous switches: proteins, glycoproteins and other components of the cell membrane. Recently, several cell membrane enzymes have been reported to participate in distinct steps of the cell adhesion process. Here, we review a variety of examples of membrane bound enzymes participating in adhesion of immune cells.
format	article
author	Georgina I. López-Cortés Laura Díaz-Alvarez Enrique Ortega
author_facet	Georgina I. López-Cortés Laura Díaz-Alvarez Enrique Ortega
author_sort	Georgina I. López-Cortés
title	Leukocyte Membrane Enzymes Play the Cell Adhesion Game
title_short	Leukocyte Membrane Enzymes Play the Cell Adhesion Game
title_full	Leukocyte Membrane Enzymes Play the Cell Adhesion Game
title_fullStr	Leukocyte Membrane Enzymes Play the Cell Adhesion Game
title_full_unstemmed	Leukocyte Membrane Enzymes Play the Cell Adhesion Game
title_sort	leukocyte membrane enzymes play the cell adhesion game
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d3d686dad9fb4ef08b7253049f9655bb
work_keys_str_mv	AT georginailopezcortes leukocytemembraneenzymesplaythecelladhesiongame AT lauradiazalvarez leukocytemembraneenzymesplaythecelladhesiongame AT enriqueortega leukocytemembraneenzymesplaythecelladhesiongame
_version_	1718406592171343872

Leukocyte Membrane Enzymes Play the Cell Adhesion Game

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