Association between long term exposure to particulate matter and incident hypertension in Spain
Abstract Exposure to air particulate matter has been linked with hypertension and blood pressure levels. The metabolic risks of air pollution could vary according to the specific characteristics of each area, and has not been sufficiently evaluated in Spain. We analyzed 1103 individuals, participant...
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2021
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oai:doaj.org-article:d3e50b39ca0243798b1abf0ffee615552021-12-02T19:16:19ZAssociation between long term exposure to particulate matter and incident hypertension in Spain10.1038/s41598-021-99154-72045-2322https://doaj.org/article/d3e50b39ca0243798b1abf0ffee615552021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99154-7https://doaj.org/toc/2045-2322Abstract Exposure to air particulate matter has been linked with hypertension and blood pressure levels. The metabolic risks of air pollution could vary according to the specific characteristics of each area, and has not been sufficiently evaluated in Spain. We analyzed 1103 individuals, participants in a Spanish nationwide population based cohort study (di@bet.es), who were free of hypertension at baseline (2008–2010) and completed a follow-up exam of the cohort (2016–2017). Cohort participants were assigned air pollution concentrations for particulate matter < 10 μm (PM10) and < 2.5 μm (PM2.5) during follow-up (2008–2016) obtained through modeling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model). Mean and SD concentrations of PM10 and PM2.5 were 20.17 ± 3.91 μg/m3 and 10.83 ± 2.08 μg/m3 respectively. During follow-up 282 cases of incident hypertension were recorded. In the fully adjusted model, compared with the lowest quartile of PM10, the multivariate weighted ORs (95% CIs) for developing hypertension with increasing PM10 exposures were 0.82 (0.59–1.14), 1.28 (0.93–1.78) and 1.45 (1.05–2.01) in quartile 2, 3 and 4 respectively (p for a trend of 0.003). The corresponding weighted ORs according to PM2.5 exposures were 0.80 (0.57–1.13), 1.11 (0.80–1.53) and 1.48 (1.09–2.00) (p for trend 0.004). For each 5-μg/m3 increment in PM10 and PM2.5 concentrations, the odds for incident hypertension increased 1.22 (1.06–1.41) p = 0.007 and 1.39 (1.07–1.81) p = 0.02 respectively. In conclusion, our study contributes to assessing the impact of particulate pollution on the incidence of hypertension in Spain, reinforcing the need for improving air quality as much as possible in order to decrease the risk of cardiometabolic disease in the population.Viyey Doulatram-GamgaramSergio ValdésCristina Maldonado-AraqueAna Lago-SampedroRocío Badía-GuillénEva García-EscobarSara García-SerranoMarta García-VivancoJuan Luis GarridoMark Richard TheobaldVictoria GilFernando Martín-LlorenteAlfonso Calle-PascualElena BordiuLuis CastañoElías DelgadoJosep Franch-NadalF. Javier ChavesEduard MontanyaJosé Luis Galán-GarcíaGabriel Aguilera-VenegasFederico SoriguerGemma Rojo-MartínezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Viyey Doulatram-Gamgaram Sergio Valdés Cristina Maldonado-Araque Ana Lago-Sampedro Rocío Badía-Guillén Eva García-Escobar Sara García-Serrano Marta García-Vivanco Juan Luis Garrido Mark Richard Theobald Victoria Gil Fernando Martín-Llorente Alfonso Calle-Pascual Elena Bordiu Luis Castaño Elías Delgado Josep Franch-Nadal F. Javier Chaves Eduard Montanya José Luis Galán-García Gabriel Aguilera-Venegas Federico Soriguer Gemma Rojo-Martínez Association between long term exposure to particulate matter and incident hypertension in Spain |
| description |
Abstract Exposure to air particulate matter has been linked with hypertension and blood pressure levels. The metabolic risks of air pollution could vary according to the specific characteristics of each area, and has not been sufficiently evaluated in Spain. We analyzed 1103 individuals, participants in a Spanish nationwide population based cohort study (di@bet.es), who were free of hypertension at baseline (2008–2010) and completed a follow-up exam of the cohort (2016–2017). Cohort participants were assigned air pollution concentrations for particulate matter < 10 μm (PM10) and < 2.5 μm (PM2.5) during follow-up (2008–2016) obtained through modeling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model). Mean and SD concentrations of PM10 and PM2.5 were 20.17 ± 3.91 μg/m3 and 10.83 ± 2.08 μg/m3 respectively. During follow-up 282 cases of incident hypertension were recorded. In the fully adjusted model, compared with the lowest quartile of PM10, the multivariate weighted ORs (95% CIs) for developing hypertension with increasing PM10 exposures were 0.82 (0.59–1.14), 1.28 (0.93–1.78) and 1.45 (1.05–2.01) in quartile 2, 3 and 4 respectively (p for a trend of 0.003). The corresponding weighted ORs according to PM2.5 exposures were 0.80 (0.57–1.13), 1.11 (0.80–1.53) and 1.48 (1.09–2.00) (p for trend 0.004). For each 5-μg/m3 increment in PM10 and PM2.5 concentrations, the odds for incident hypertension increased 1.22 (1.06–1.41) p = 0.007 and 1.39 (1.07–1.81) p = 0.02 respectively. In conclusion, our study contributes to assessing the impact of particulate pollution on the incidence of hypertension in Spain, reinforcing the need for improving air quality as much as possible in order to decrease the risk of cardiometabolic disease in the population. |
| format |
article |
| author |
Viyey Doulatram-Gamgaram Sergio Valdés Cristina Maldonado-Araque Ana Lago-Sampedro Rocío Badía-Guillén Eva García-Escobar Sara García-Serrano Marta García-Vivanco Juan Luis Garrido Mark Richard Theobald Victoria Gil Fernando Martín-Llorente Alfonso Calle-Pascual Elena Bordiu Luis Castaño Elías Delgado Josep Franch-Nadal F. Javier Chaves Eduard Montanya José Luis Galán-García Gabriel Aguilera-Venegas Federico Soriguer Gemma Rojo-Martínez |
| author_facet |
Viyey Doulatram-Gamgaram Sergio Valdés Cristina Maldonado-Araque Ana Lago-Sampedro Rocío Badía-Guillén Eva García-Escobar Sara García-Serrano Marta García-Vivanco Juan Luis Garrido Mark Richard Theobald Victoria Gil Fernando Martín-Llorente Alfonso Calle-Pascual Elena Bordiu Luis Castaño Elías Delgado Josep Franch-Nadal F. Javier Chaves Eduard Montanya José Luis Galán-García Gabriel Aguilera-Venegas Federico Soriguer Gemma Rojo-Martínez |
| author_sort |
Viyey Doulatram-Gamgaram |
| title |
Association between long term exposure to particulate matter and incident hypertension in Spain |
| title_short |
Association between long term exposure to particulate matter and incident hypertension in Spain |
| title_full |
Association between long term exposure to particulate matter and incident hypertension in Spain |
| title_fullStr |
Association between long term exposure to particulate matter and incident hypertension in Spain |
| title_full_unstemmed |
Association between long term exposure to particulate matter and incident hypertension in Spain |
| title_sort |
association between long term exposure to particulate matter and incident hypertension in spain |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d3e50b39ca0243798b1abf0ffee61555 |
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