Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis

Abstract This study aimed to investigate immune-related pathophysiology of the temporomandibular joint (TMJ) osteoarthritis (OA) in young females by analyzing transcriptional profiles of peripheral blood mononuclear cells. The RNA-sequencing (RNA-seq) was conducted on 24 young females with TMJ OA (m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Jeong-Hyun Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d3e6498dc82145f79608d7937c6af97e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d3e6498dc82145f79608d7937c6af97e
record_format	dspace
spelling	oai:doaj.org-article:d3e6498dc82145f79608d7937c6af97e2021-12-02T17:32:57ZTranscriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis10.1038/s41598-021-88275-82045-2322https://doaj.org/article/d3e6498dc82145f79608d7937c6af97e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88275-8https://doaj.org/toc/2045-2322Abstract This study aimed to investigate immune-related pathophysiology of the temporomandibular joint (TMJ) osteoarthritis (OA) in young females by analyzing transcriptional profiles of peripheral blood mononuclear cells. The RNA-sequencing (RNA-seq) was conducted on 24 young females with TMJ OA (mean age 19.3 ± 3.1 years) (RNAOA) and 11 age and sex matched healthy controls (mean age 20.5 ± 3.7 years) (CON). RNA-seq datasets were analyzed to identify genes, pathways, and regulatory networks of those which were involved in the development of TMJ OA. RNA-seq data analysis revealed 41 differentially expressed genes (DEGs) between RNAOA and CON. A total of 16 gene ontology (GO) terms including three molecular and 13 biological terms were annotated via the GO function of molecular function and biological process. Through ingenuity pathway analysis (IPA), 21 annotated categories of diseases and functions were identified. There were six hub genes which showed significant results in both GO enrichment analysis and IPA, namely HLA-C, HLA-F, CXCL8, IL11RA, IL13RA1, and FCGR3B. The young females with TMJ OA showed alterations of the genes related to immune function in the blood and some of changes may reflect inflammation, autoimmunity, and abnormal T cell functions.Jeong-Hyun KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeong-Hyun Kang Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis
description	Abstract This study aimed to investigate immune-related pathophysiology of the temporomandibular joint (TMJ) osteoarthritis (OA) in young females by analyzing transcriptional profiles of peripheral blood mononuclear cells. The RNA-sequencing (RNA-seq) was conducted on 24 young females with TMJ OA (mean age 19.3 ± 3.1 years) (RNAOA) and 11 age and sex matched healthy controls (mean age 20.5 ± 3.7 years) (CON). RNA-seq datasets were analyzed to identify genes, pathways, and regulatory networks of those which were involved in the development of TMJ OA. RNA-seq data analysis revealed 41 differentially expressed genes (DEGs) between RNAOA and CON. A total of 16 gene ontology (GO) terms including three molecular and 13 biological terms were annotated via the GO function of molecular function and biological process. Through ingenuity pathway analysis (IPA), 21 annotated categories of diseases and functions were identified. There were six hub genes which showed significant results in both GO enrichment analysis and IPA, namely HLA-C, HLA-F, CXCL8, IL11RA, IL13RA1, and FCGR3B. The young females with TMJ OA showed alterations of the genes related to immune function in the blood and some of changes may reflect inflammation, autoimmunity, and abnormal T cell functions.
format	article
author	Jeong-Hyun Kang
author_facet	Jeong-Hyun Kang
author_sort	Jeong-Hyun Kang
title	Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis
title_short	Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis
title_full	Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis
title_fullStr	Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis
title_full_unstemmed	Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis
title_sort	transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d3e6498dc82145f79608d7937c6af97e
work_keys_str_mv	AT jeonghyunkang transcriptomesinperipheralbloodofyoungfemaleswithtemporomandibularjointosteoarthritis
_version_	1718380151304093696

Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis

Ejemplares similares