Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion

The NLRP3 inflammasome plays an important role in antiviral host responses. Here, the authors reveal that the polymerase of Zika virus binds NLRP3 to facilitate inflammasome complex assembly and induce production of IL-1β in human macrophages, human PBMCs and mice, resulting in pathogenesis in mice....

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Autores principales:	Wenbiao Wang, Geng Li, De Wu, Zhen Luo, Pan Pan, Mingfu Tian, Yingchong Wang, Feng Xiao, Aixin Li, Kailang Wu, Xiaohong Liu, Lang Rao, Fang Liu, Yingle Liu, Jianguo Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d3ea3c77bb8f47dd80e55a66920d4519
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spelling	oai:doaj.org-article:d3ea3c77bb8f47dd80e55a66920d45192021-12-02T15:33:35ZZika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion10.1038/s41467-017-02645-32041-1723https://doaj.org/article/d3ea3c77bb8f47dd80e55a66920d45192018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02645-3https://doaj.org/toc/2041-1723The NLRP3 inflammasome plays an important role in antiviral host responses. Here, the authors reveal that the polymerase of Zika virus binds NLRP3 to facilitate inflammasome complex assembly and induce production of IL-1β in human macrophages, human PBMCs and mice, resulting in pathogenesis in mice.Wenbiao WangGeng LiDe WuZhen LuoPan PanMingfu TianYingchong WangFeng XiaoAixin LiKailang WuXiaohong LiuLang RaoFang LiuYingle LiuJianguo WuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenbiao Wang Geng Li De Wu Zhen Luo Pan Pan Mingfu Tian Yingchong Wang Feng Xiao Aixin Li Kailang Wu Xiaohong Liu Lang Rao Fang Liu Yingle Liu Jianguo Wu Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion
description	The NLRP3 inflammasome plays an important role in antiviral host responses. Here, the authors reveal that the polymerase of Zika virus binds NLRP3 to facilitate inflammasome complex assembly and induce production of IL-1β in human macrophages, human PBMCs and mice, resulting in pathogenesis in mice.
format	article
author	Wenbiao Wang Geng Li De Wu Zhen Luo Pan Pan Mingfu Tian Yingchong Wang Feng Xiao Aixin Li Kailang Wu Xiaohong Liu Lang Rao Fang Liu Yingle Liu Jianguo Wu
author_facet	Wenbiao Wang Geng Li De Wu Zhen Luo Pan Pan Mingfu Tian Yingchong Wang Feng Xiao Aixin Li Kailang Wu Xiaohong Liu Lang Rao Fang Liu Yingle Liu Jianguo Wu
author_sort	Wenbiao Wang
title	Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion
title_short	Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion
title_full	Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion
title_fullStr	Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion
title_full_unstemmed	Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion
title_sort	zika virus infection induces host inflammatory responses by facilitating nlrp3 inflammasome assembly and interleukin-1β secretion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d3ea3c77bb8f47dd80e55a66920d4519
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Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion

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