Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis

Abstract The myeloid inhibitory receptor CLEC12A negatively regulates inflammation. Reduced CLEC12A expression enhances inflammation in CLEC12A knock-out mice with collagen antibody-induced arthritis. Moreover, CLEC12A internalisation augments human neutrophil activation. We thus postulated that CLE...

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Autores principales:	Myriam Vaillancourt, Philippe Desaulniers, Guillaume Paré, Nathalie Pagé, Asmaa Lachhab, Anthony Kerever, Anne-Sophie Julien, Nathalie Amiable, Martin Pelletier, Philippe A. Tessier, Louis Bessette, Laëtitia Michou, Paul R. Fortin, Maria J. Fernandes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d3ee78915a5744e59fad0e79ca0e020a
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spelling	oai:doaj.org-article:d3ee78915a5744e59fad0e79ca0e020a2021-12-02T14:49:18ZExpression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis10.1038/s41598-021-90631-72045-2322https://doaj.org/article/d3ee78915a5744e59fad0e79ca0e020a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90631-7https://doaj.org/toc/2045-2322Abstract The myeloid inhibitory receptor CLEC12A negatively regulates inflammation. Reduced CLEC12A expression enhances inflammation in CLEC12A knock-out mice with collagen antibody-induced arthritis. Moreover, CLEC12A internalisation augments human neutrophil activation. We thus postulated that CLEC12A expression on circulating myeloid cells of rheumatoid arthritis patients is associated with disease manifestations. Cell-surface, CLEC12A receptor expression was determined on circulating neutrophils and monocytes of eRA patients and of healthy donors. Generalized estimating equations model, Student’s t-test and Spearman’s correlations were performed to compare CLEC12A expression between groups and test its association with disease activity and clinical parameters. Plasma cytokines were measured by multiplex immunoassay. Patients with reduced neutrophil or monocyte CLEC12A expression at baseline and at 3 months have an increased simple disease activity index. Low baseline CLEC12A expression also correlates with a higher SDAI at 6 months. In contrast, positive correlations were observed between baseline CLEC12A expression and several cytokines. Moreover, neutrophil and monocyte CLEC12A expression is significantly higher in early rheumatoid arthritis patients at baseline than healthy controls. Circulating neutrophil and monocyte CLEC12A expression correlates with disease activity at baseline and is predictive of SDAI at later stages of the disease indicative of a regulatory role for CLEC12A in RA.Myriam VaillancourtPhilippe DesaulniersGuillaume ParéNathalie PagéAsmaa LachhabAnthony KereverAnne-Sophie JulienNathalie AmiableMartin PelletierPhilippe A. TessierLouis BessetteLaëtitia MichouPaul R. FortinMaria J. FernandesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Myriam Vaillancourt Philippe Desaulniers Guillaume Paré Nathalie Pagé Asmaa Lachhab Anthony Kerever Anne-Sophie Julien Nathalie Amiable Martin Pelletier Philippe A. Tessier Louis Bessette Laëtitia Michou Paul R. Fortin Maria J. Fernandes Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis
description	Abstract The myeloid inhibitory receptor CLEC12A negatively regulates inflammation. Reduced CLEC12A expression enhances inflammation in CLEC12A knock-out mice with collagen antibody-induced arthritis. Moreover, CLEC12A internalisation augments human neutrophil activation. We thus postulated that CLEC12A expression on circulating myeloid cells of rheumatoid arthritis patients is associated with disease manifestations. Cell-surface, CLEC12A receptor expression was determined on circulating neutrophils and monocytes of eRA patients and of healthy donors. Generalized estimating equations model, Student’s t-test and Spearman’s correlations were performed to compare CLEC12A expression between groups and test its association with disease activity and clinical parameters. Plasma cytokines were measured by multiplex immunoassay. Patients with reduced neutrophil or monocyte CLEC12A expression at baseline and at 3 months have an increased simple disease activity index. Low baseline CLEC12A expression also correlates with a higher SDAI at 6 months. In contrast, positive correlations were observed between baseline CLEC12A expression and several cytokines. Moreover, neutrophil and monocyte CLEC12A expression is significantly higher in early rheumatoid arthritis patients at baseline than healthy controls. Circulating neutrophil and monocyte CLEC12A expression correlates with disease activity at baseline and is predictive of SDAI at later stages of the disease indicative of a regulatory role for CLEC12A in RA.
format	article
author	Myriam Vaillancourt Philippe Desaulniers Guillaume Paré Nathalie Pagé Asmaa Lachhab Anthony Kerever Anne-Sophie Julien Nathalie Amiable Martin Pelletier Philippe A. Tessier Louis Bessette Laëtitia Michou Paul R. Fortin Maria J. Fernandes
author_facet	Myriam Vaillancourt Philippe Desaulniers Guillaume Paré Nathalie Pagé Asmaa Lachhab Anthony Kerever Anne-Sophie Julien Nathalie Amiable Martin Pelletier Philippe A. Tessier Louis Bessette Laëtitia Michou Paul R. Fortin Maria J. Fernandes
author_sort	Myriam Vaillancourt
title	Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis
title_short	Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis
title_full	Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis
title_fullStr	Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis
title_full_unstemmed	Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis
title_sort	expression of the myeloid inhibitory receptor clec12a correlates with disease activity and cytokines in early rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d3ee78915a5744e59fad0e79ca0e020a
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Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis

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