Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis

Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis

Abstract The myeloid inhibitory receptor CLEC12A negatively regulates inflammation. Reduced CLEC12A expression enhances inflammation in CLEC12A knock-out mice with collagen antibody-induced arthritis. Moreover, CLEC12A internalisation augments human neutrophil activation. We thus postulated that CLE...

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Main Authors: Myriam Vaillancourt, Philippe Desaulniers, Guillaume Paré, Nathalie Pagé, Asmaa Lachhab, Anthony Kerever, Anne-Sophie Julien, Nathalie Amiable, Martin Pelletier, Philippe A. Tessier, Louis Bessette, Laëtitia Michou, Paul R. Fortin, Maria J. Fernandes
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/d3ee78915a5744e59fad0e79ca0e020a
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https://doaj.org/article/d3ee78915a5744e59fad0e79ca0e020a

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