Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy
Elevated MYC levels can sensitize tumor cells to apoptosis. In this study, the authors demonstrate that AMPK activation and BCL-2/BCL-XL inhibition have a synergistic effect on apoptosis, and that together with anti PD-1 therapy they can suppress Myc-driven mammary tumor growth.
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2019
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oai:doaj.org-article:d3f1f919795e44fe8702e5ba84a712b62021-12-02T14:39:36ZPharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy10.1038/s41467-019-08541-22041-1723https://doaj.org/article/d3f1f919795e44fe8702e5ba84a712b62019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08541-2https://doaj.org/toc/2041-1723Elevated MYC levels can sensitize tumor cells to apoptosis. In this study, the authors demonstrate that AMPK activation and BCL-2/BCL-XL inhibition have a synergistic effect on apoptosis, and that together with anti PD-1 therapy they can suppress Myc-driven mammary tumor growth.Heidi M. HaikalaJohanna M. AnttilaElsa MarquesTiina RaatikainenMette IlanderHenna HakanenHanna Ala-HongistoMariel SaveliusDiego BalboaBjoern Von EyssVilja EskelinenPauliina MunneAnni I. NieminenTimo OtonkoskiJulia SchülerTeemu D. LaajalaTero AittokallioHarri SihtoJohanna MattsonPäivi HeikkiläMarjut LeideniusHeikki JoensuuSatu MustjokiPanu KovanenMartin EilersJoel D. LeversonJuha KlefströmNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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DOAJ |
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EN |
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Science Q |
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Science Q Heidi M. Haikala Johanna M. Anttila Elsa Marques Tiina Raatikainen Mette Ilander Henna Hakanen Hanna Ala-Hongisto Mariel Savelius Diego Balboa Bjoern Von Eyss Vilja Eskelinen Pauliina Munne Anni I. Nieminen Timo Otonkoski Julia Schüler Teemu D. Laajala Tero Aittokallio Harri Sihto Johanna Mattson Päivi Heikkilä Marjut Leidenius Heikki Joensuu Satu Mustjoki Panu Kovanen Martin Eilers Joel D. Leverson Juha Klefström Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy |
| description |
Elevated MYC levels can sensitize tumor cells to apoptosis. In this study, the authors demonstrate that AMPK activation and BCL-2/BCL-XL inhibition have a synergistic effect on apoptosis, and that together with anti PD-1 therapy they can suppress Myc-driven mammary tumor growth. |
| format |
article |
| author |
Heidi M. Haikala Johanna M. Anttila Elsa Marques Tiina Raatikainen Mette Ilander Henna Hakanen Hanna Ala-Hongisto Mariel Savelius Diego Balboa Bjoern Von Eyss Vilja Eskelinen Pauliina Munne Anni I. Nieminen Timo Otonkoski Julia Schüler Teemu D. Laajala Tero Aittokallio Harri Sihto Johanna Mattson Päivi Heikkilä Marjut Leidenius Heikki Joensuu Satu Mustjoki Panu Kovanen Martin Eilers Joel D. Leverson Juha Klefström |
| author_facet |
Heidi M. Haikala Johanna M. Anttila Elsa Marques Tiina Raatikainen Mette Ilander Henna Hakanen Hanna Ala-Hongisto Mariel Savelius Diego Balboa Bjoern Von Eyss Vilja Eskelinen Pauliina Munne Anni I. Nieminen Timo Otonkoski Julia Schüler Teemu D. Laajala Tero Aittokallio Harri Sihto Johanna Mattson Päivi Heikkilä Marjut Leidenius Heikki Joensuu Satu Mustjoki Panu Kovanen Martin Eilers Joel D. Leverson Juha Klefström |
| author_sort |
Heidi M. Haikala |
| title |
Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy |
| title_short |
Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy |
| title_full |
Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy |
| title_fullStr |
Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy |
| title_full_unstemmed |
Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy |
| title_sort |
pharmacological reactivation of myc-dependent apoptosis induces susceptibility to anti-pd-1 immunotherapy |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/d3f1f919795e44fe8702e5ba84a712b6 |
| work_keys_str_mv |
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1718390561362149376 |