Prenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico

Background: The Child-Mother binomial is potentially susceptible to the toxic effects of pollutants because some chemicals interfere with placental transfer of nutrients, thus affecting fetal development, and create an increased the risk of low birth weight, prematurity and intrauterine growth restr...

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Autores principales:	Jessica Mendoza-Ramirez, Albino Barraza-Villarreal, Leticia Hernandez-Cadena, Octavio Hinojosa de la Garza, José Luis Texcalac Sangrador, Luisa Elvira Torres-Sanchez, Marlene Cortez-Lugo, Consuelo Escamilla-Nuñez, Luz Helena Sanin-Aguirre, Isabelle Romieu
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2018
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/d3f3cf9768024150ab2c046db75a92d4
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spelling	oai:doaj.org-article:d3f3cf9768024150ab2c046db75a92d42021-12-02T04:21:57ZPrenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico2214-999610.29024/aogh.914https://doaj.org/article/d3f3cf9768024150ab2c046db75a92d42018-07-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/914https://doaj.org/toc/2214-9996Background: The Child-Mother binomial is potentially susceptible to the toxic effects of pollutants because some chemicals interfere with placental transfer of nutrients, thus affecting fetal development, and create an increased the risk of low birth weight, prematurity and intrauterine growth restriction. Objective: To evaluate the impact of prenatal exposure to nitrogen oxides (NOx) on birth weight in a cohort of Mexican newborns. Methodology: We included 745 mother-child pair participants of the POSGRAD cohort study. Information on socio-demographic characteristics, obstetric history, health history and environmental exposure during pregnancy were readily available and the newborns’ anthropometric measurements were obtained at delivery. Prenatal NOx exposure assessment was evaluated using a Land-Use Regression predictive models considering local monitoring from 60 sites on the State of Morelos. The association between prenatal exposure to NOx and birth weight was estimated using a multivariate linear regression models. Results: The average birth weight was 3217 ± 439 g and the mean of NOx concentration was 21 ppb (Interquartile range, IQR = 6.95 ppb). After adjusting for maternal age and other confounders, a significant birthweight reduction was observed for each IQR of NOx increase (ß = −39.61 g, 95% CI: −77.00; −2.21; p = 0.04). Conclusions: Our results provides evidence that prenatal NOx exposure has a negative effect on birth weight, which may influence the growth and future development of the newborn.</p><p>Jessica Mendoza-RamirezAlbino Barraza-VillarrealLeticia Hernandez-CadenaOctavio Hinojosa de la GarzaJosé Luis Texcalac SangradorLuisa Elvira Torres-SanchezMarlene Cortez-LugoConsuelo Escamilla-NuñezLuz Helena Sanin-AguirreIsabelle RomieuUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 84, Iss 2, Pp 274-280 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Jessica Mendoza-Ramirez Albino Barraza-Villarreal Leticia Hernandez-Cadena Octavio Hinojosa de la Garza José Luis Texcalac Sangrador Luisa Elvira Torres-Sanchez Marlene Cortez-Lugo Consuelo Escamilla-Nuñez Luz Helena Sanin-Aguirre Isabelle Romieu Prenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico
description	Background: The Child-Mother binomial is potentially susceptible to the toxic effects of pollutants because some chemicals interfere with placental transfer of nutrients, thus affecting fetal development, and create an increased the risk of low birth weight, prematurity and intrauterine growth restriction. Objective: To evaluate the impact of prenatal exposure to nitrogen oxides (NOx) on birth weight in a cohort of Mexican newborns. Methodology: We included 745 mother-child pair participants of the POSGRAD cohort study. Information on socio-demographic characteristics, obstetric history, health history and environmental exposure during pregnancy were readily available and the newborns’ anthropometric measurements were obtained at delivery. Prenatal NOx exposure assessment was evaluated using a Land-Use Regression predictive models considering local monitoring from 60 sites on the State of Morelos. The association between prenatal exposure to NOx and birth weight was estimated using a multivariate linear regression models. Results: The average birth weight was 3217 ± 439 g and the mean of NOx concentration was 21 ppb (Interquartile range, IQR = 6.95 ppb). After adjusting for maternal age and other confounders, a significant birthweight reduction was observed for each IQR of NOx increase (ß = −39.61 g, 95% CI: −77.00; −2.21; p = 0.04). Conclusions: Our results provides evidence that prenatal NOx exposure has a negative effect on birth weight, which may influence the growth and future development of the newborn.</p><p>
format	article
author	Jessica Mendoza-Ramirez Albino Barraza-Villarreal Leticia Hernandez-Cadena Octavio Hinojosa de la Garza José Luis Texcalac Sangrador Luisa Elvira Torres-Sanchez Marlene Cortez-Lugo Consuelo Escamilla-Nuñez Luz Helena Sanin-Aguirre Isabelle Romieu
author_facet	Jessica Mendoza-Ramirez Albino Barraza-Villarreal Leticia Hernandez-Cadena Octavio Hinojosa de la Garza José Luis Texcalac Sangrador Luisa Elvira Torres-Sanchez Marlene Cortez-Lugo Consuelo Escamilla-Nuñez Luz Helena Sanin-Aguirre Isabelle Romieu
author_sort	Jessica Mendoza-Ramirez
title	Prenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico
title_short	Prenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico
title_full	Prenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico
title_fullStr	Prenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico
title_full_unstemmed	Prenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico
title_sort	prenatal exposure to nitrogen oxides and its association with birth weight in a cohort of mexican newborns from morelos, mexico
publisher	Ubiquity Press
publishDate	2018
url	https://doaj.org/article/d3f3cf9768024150ab2c046db75a92d4
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Prenatal Exposure to Nitrogen Oxides and its Association with Birth Weight in a Cohort of Mexican Newborns from Morelos, Mexico

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