Novel conditioning regimens for bone marrow transplantation

Ming Shi, Ming Li, Susumu IkeharaDepartment of Stem Cell Disorders, Kansai Medical University, Moriguchi City, Osaka, JapanAbstract: Bone marrow transplantation (BMT) has evolved into an effective strategy for the treatment of hematological and oncological disorders. Radiotherapy and chemotherapy ar...

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Autores principales:	Shi M, Li M, Ikehara S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/d3f6b6e12610425ebe61c3909e5667e0
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spelling	oai:doaj.org-article:d3f6b6e12610425ebe61c3909e5667e02021-12-02T00:44:54ZNovel conditioning regimens for bone marrow transplantation1179-9889https://doaj.org/article/d3f6b6e12610425ebe61c3909e5667e02013-01-01T00:00:00Zhttp://www.dovepress.com/novel-conditioning-regimens-for-bone-marrow-transplantation-a11894https://doaj.org/toc/1179-9889Ming Shi, Ming Li, Susumu IkeharaDepartment of Stem Cell Disorders, Kansai Medical University, Moriguchi City, Osaka, JapanAbstract: Bone marrow transplantation (BMT) has evolved into an effective strategy for the treatment of hematological and oncological disorders. Radiotherapy and chemotherapy are used as conditioning regimens prior to BMT to suppress host immunity and reduce tumor burden. High doses of total body irradiation are conventionally administered along with alkylating agents, ie, the myeloablative regimen, to help ensure rapid engraftment of donor cells and to prevent relapse. However, the toxicity of the myeloablative conditioning regimen and unacceptable nonrelapse mortality rules out this approach for older patients by whom less intense preparative regimens are likely to be better tolerated. The reduced-intensity and nonmyeloablative conditioning regimens have been demonstrated by many investigators to be novel approaches resulting in a lower nonrelapse mortality rate and lower incidence of severe acute graft versus host disease. Here, we review the conditioning regimens employed as a pretreatment for BMT, and focus on the novel conditioning regimens and cutting edge developments.Keywords: myeloablative conditioning regimen, reduced-intensity conditioning, nonmyeloablative conditioning regimen, relapse, nonrelapse mortality, graft versus host diseaseShi MLi MIkehara SDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2013, Iss default, Pp 1-9 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Shi M Li M Ikehara S Novel conditioning regimens for bone marrow transplantation
description	Ming Shi, Ming Li, Susumu IkeharaDepartment of Stem Cell Disorders, Kansai Medical University, Moriguchi City, Osaka, JapanAbstract: Bone marrow transplantation (BMT) has evolved into an effective strategy for the treatment of hematological and oncological disorders. Radiotherapy and chemotherapy are used as conditioning regimens prior to BMT to suppress host immunity and reduce tumor burden. High doses of total body irradiation are conventionally administered along with alkylating agents, ie, the myeloablative regimen, to help ensure rapid engraftment of donor cells and to prevent relapse. However, the toxicity of the myeloablative conditioning regimen and unacceptable nonrelapse mortality rules out this approach for older patients by whom less intense preparative regimens are likely to be better tolerated. The reduced-intensity and nonmyeloablative conditioning regimens have been demonstrated by many investigators to be novel approaches resulting in a lower nonrelapse mortality rate and lower incidence of severe acute graft versus host disease. Here, we review the conditioning regimens employed as a pretreatment for BMT, and focus on the novel conditioning regimens and cutting edge developments.Keywords: myeloablative conditioning regimen, reduced-intensity conditioning, nonmyeloablative conditioning regimen, relapse, nonrelapse mortality, graft versus host disease
format	article
author	Shi M Li M Ikehara S
author_facet	Shi M Li M Ikehara S
author_sort	Shi M
title	Novel conditioning regimens for bone marrow transplantation
title_short	Novel conditioning regimens for bone marrow transplantation
title_full	Novel conditioning regimens for bone marrow transplantation
title_fullStr	Novel conditioning regimens for bone marrow transplantation
title_full_unstemmed	Novel conditioning regimens for bone marrow transplantation
title_sort	novel conditioning regimens for bone marrow transplantation
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d3f6b6e12610425ebe61c3909e5667e0
work_keys_str_mv	AT shim novelconditioningregimensforbonemarrowtransplantation AT lim novelconditioningregimensforbonemarrowtransplantation AT ikeharas novelconditioningregimensforbonemarrowtransplantation
_version_	1718403527081984000

Novel conditioning regimens for bone marrow transplantation

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