Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention

Alireza Rahimi,1 Mohammad Ahmadpanah,1 Farshid Shamsaei,1 Fatemeh Cheraghi,2 Dena Sadeghi Bahmani,3 Edith Holsboer-Trachsler,3 Serge Brand3,4 1Behavioral Disorders and Substances Abuses Research Center, Hamadan University of Medial Sciences, Hamadan, 2Research Center for Chronic Disease Care at Hom...

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Autores principales:	Rahimi A, Ahmadpanah M, Shamsaei F, Cheraghi F, Sadeghi Bahmani D, Holsboer-Trachsler E, Br, S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	sleep hygiene psychoeducation pharmacotherapy lorazepam sleep disturbances depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d3fce70165a641efbab545b4439bd65a
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spelling	oai:doaj.org-article:d3fce70165a641efbab545b4439bd65a2021-12-02T11:02:45ZEffect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention1178-2021https://doaj.org/article/d3fce70165a641efbab545b4439bd65a2016-06-01T00:00:00Zhttps://www.dovepress.com/effect-of-adjuvant-sleep-hygiene-psychoeducation-and-lorazepam-on-depr-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Alireza Rahimi,1 Mohammad Ahmadpanah,1 Farshid Shamsaei,1 Fatemeh Cheraghi,2 Dena Sadeghi Bahmani,3 Edith Holsboer-Trachsler,3 Serge Brand3,4 1Behavioral Disorders and Substances Abuses Research Center, Hamadan University of Medial Sciences, Hamadan, 2Research Center for Chronic Disease Care at Home, Hamadan University of Medial Sciences, Hamadan, Iran; 3Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders (ZASS), 4Department of Sport, Exercise, and Health, Division of Sport and Psychosocial Health, University of Basel, Basel, Switzerland Background: Sleep disturbances are a common co-occurring disturbance in patients with major depressive disorders (MDDs) and accordingly deserve particular attention. Using a randomized design, we investigated the effects of three different adjuvant interventions on sleep and depression among patients with MDD: a sleep hygiene program (SHP), lorazepam (LOR), and their combination (SHP–LOR). Methods: A total of 120 outpatients with diagnosed MDD (mean age: 48.25 years; 56.7% females) and treated with a standard SSRI (citalopram at 20–40 mg at therapeutic level) were randomly assigned to one of the following three conditions: SHP (n=40), LOR (1 mg/d; n=40), SHP–LOR (1 mg/d; n=40). At the beginning and at the end of the study 8 weeks later, patients completed two questionnaires, the Pittsburgh Sleep Quality Index to assess sleep and the Beck Depression Inventory to assess symptoms of depression. Results: Sleep disturbances decreased over time and in all groups. No group differences or interactions were observed. Symptoms of depression decreased over time and in all three groups. Reduction in symptoms of depression was greatest in the SHP–LOR group and lowest in the LOR group. Conclusion: The pattern of results suggests that all three adjuvant treatments improved symptoms of sleep disturbances and depression, with greater benefits for the SHP–LOR for symptoms of depression, but not for sleep. Nevertheless, risks and benefits of benzodiazepine prescriptions should be taken into account. Keywords: sleep hygiene, psychoeducation, pharmacotherapy, lorazepam, sleep disturbances, depressionRahimi AAhmadpanah MShamsaei FCheraghi FSadeghi Bahmani DHolsboer-Trachsler EBrSDove Medical Pressarticlesleep hygienepsychoeducationpharmacotherapylorazepamsleep disturbancesdepressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1507-1515 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep hygiene psychoeducation pharmacotherapy lorazepam sleep disturbances depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	sleep hygiene psychoeducation pharmacotherapy lorazepam sleep disturbances depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Rahimi A Ahmadpanah M Shamsaei F Cheraghi F Sadeghi Bahmani D Holsboer-Trachsler E Br S Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention
description	Alireza Rahimi,1 Mohammad Ahmadpanah,1 Farshid Shamsaei,1 Fatemeh Cheraghi,2 Dena Sadeghi Bahmani,3 Edith Holsboer-Trachsler,3 Serge Brand3,4 1Behavioral Disorders and Substances Abuses Research Center, Hamadan University of Medial Sciences, Hamadan, 2Research Center for Chronic Disease Care at Home, Hamadan University of Medial Sciences, Hamadan, Iran; 3Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders (ZASS), 4Department of Sport, Exercise, and Health, Division of Sport and Psychosocial Health, University of Basel, Basel, Switzerland Background: Sleep disturbances are a common co-occurring disturbance in patients with major depressive disorders (MDDs) and accordingly deserve particular attention. Using a randomized design, we investigated the effects of three different adjuvant interventions on sleep and depression among patients with MDD: a sleep hygiene program (SHP), lorazepam (LOR), and their combination (SHP–LOR). Methods: A total of 120 outpatients with diagnosed MDD (mean age: 48.25 years; 56.7% females) and treated with a standard SSRI (citalopram at 20–40 mg at therapeutic level) were randomly assigned to one of the following three conditions: SHP (n=40), LOR (1 mg/d; n=40), SHP–LOR (1 mg/d; n=40). At the beginning and at the end of the study 8 weeks later, patients completed two questionnaires, the Pittsburgh Sleep Quality Index to assess sleep and the Beck Depression Inventory to assess symptoms of depression. Results: Sleep disturbances decreased over time and in all groups. No group differences or interactions were observed. Symptoms of depression decreased over time and in all three groups. Reduction in symptoms of depression was greatest in the SHP–LOR group and lowest in the LOR group. Conclusion: The pattern of results suggests that all three adjuvant treatments improved symptoms of sleep disturbances and depression, with greater benefits for the SHP–LOR for symptoms of depression, but not for sleep. Nevertheless, risks and benefits of benzodiazepine prescriptions should be taken into account. Keywords: sleep hygiene, psychoeducation, pharmacotherapy, lorazepam, sleep disturbances, depression
format	article
author	Rahimi A Ahmadpanah M Shamsaei F Cheraghi F Sadeghi Bahmani D Holsboer-Trachsler E Br S
author_facet	Rahimi A Ahmadpanah M Shamsaei F Cheraghi F Sadeghi Bahmani D Holsboer-Trachsler E Br S
author_sort	Rahimi A
title	Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention
title_short	Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention
title_full	Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention
title_fullStr	Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention
title_full_unstemmed	Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention
title_sort	effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d3fce70165a641efbab545b4439bd65a
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Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention

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