The diurnal and nocturnal effects of travoprost in normal-tension glaucoma
Leonard K Seibold, Malik Y KahookDepartment of Ophthalmology, University of Colorado Eye Center, Aurora, CO, USAPurpose: To determine the diurnal and nocturnal effects of travoprost with sofZia® (Travatan Z® [TZ]) on intraocular pressure (IOP) and ocular perfusion pressure...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2014
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| Acceso en línea: | https://doaj.org/article/d4000ed9c4334551af0ab36e1ef717ea |
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| Sumario: | Leonard K Seibold, Malik Y KahookDepartment of Ophthalmology, University of Colorado Eye Center, Aurora, CO, USAPurpose: To determine the diurnal and nocturnal effects of travoprost with sofZia® (Travatan Z® [TZ]) on intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with normal-tension glaucoma (NTG).Methods: Twenty-seven subjects with NTG were admitted to an inpatient sleep laboratory for three 24-hour sessions monitoring IOP, blood pressure (BP), and heart rate every 2 hours in the habitual position (diurnal period: upright; nocturnal period: supine). Baseline IOP and OPP levels were compared to those during active treatment with TZ and 3 days after stopping the medication. OPP was calculated as 2/3 [diastolic BP + 1/3 (systolic BP – diastolic BP)] – IOP.Results: TZ significantly reduced the mean diurnal and nocturnal IOP levels compared to baseline at all time points. During treatment, mean IOP decreased from 17.1±3.4 to 14.7±3.0 mmHg during the diurnal period (P<0.01) and from 19.9±3.6 to 18.8±3.5 mmHg during the nocturnal period (P<0.01). Once treatment was discontinued, mean IOP remained at levels significantly less than baseline during both the diurnal (15.6±3.2 mmHg) and nocturnal (18.7±3.7 mmHg) periods. Mean OPP was not significantly changed with treatment during either period. Conclusion: In this population of NTG patients, TZ significantly lowers IOP at all time points throughout the diurnal and nocturnal periods. The treatment effect on IOP endures for up to 3 days after the last dose. Treatment did not significantly improve OPP.Keywords: ocular perfusion pressure, intraocular pressure, 24-hour, diurnal, nocturnal, sofZia® |
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