Engineered kinesin motor proteins amenable to small-molecule inhibition

The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable molecules.

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Autores principales:	Martin F. Engelke, Michael Winding, Yang Yue, Shankar Shastry, Federico Teloni, Sanjay Reddy, T. Lynne Blasius, Pushpanjali Soppina, William O. Hancock, Vladimir I. Gelfand, Kristen J. Verhey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d400141931f143c5987411f968b209bc
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spelling	oai:doaj.org-article:d400141931f143c5987411f968b209bc2021-12-02T15:35:46ZEngineered kinesin motor proteins amenable to small-molecule inhibition10.1038/ncomms111592041-1723https://doaj.org/article/d400141931f143c5987411f968b209bc2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11159https://doaj.org/toc/2041-1723The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable molecules.Martin F. EngelkeMichael WindingYang YueShankar ShastryFederico TeloniSanjay ReddyT. Lynne BlasiusPushpanjali SoppinaWilliam O. HancockVladimir I. GelfandKristen J. VerheyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin F. Engelke Michael Winding Yang Yue Shankar Shastry Federico Teloni Sanjay Reddy T. Lynne Blasius Pushpanjali Soppina William O. Hancock Vladimir I. Gelfand Kristen J. Verhey Engineered kinesin motor proteins amenable to small-molecule inhibition
description	The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable molecules.
format	article
author	Martin F. Engelke Michael Winding Yang Yue Shankar Shastry Federico Teloni Sanjay Reddy T. Lynne Blasius Pushpanjali Soppina William O. Hancock Vladimir I. Gelfand Kristen J. Verhey
author_facet	Martin F. Engelke Michael Winding Yang Yue Shankar Shastry Federico Teloni Sanjay Reddy T. Lynne Blasius Pushpanjali Soppina William O. Hancock Vladimir I. Gelfand Kristen J. Verhey
author_sort	Martin F. Engelke
title	Engineered kinesin motor proteins amenable to small-molecule inhibition
title_short	Engineered kinesin motor proteins amenable to small-molecule inhibition
title_full	Engineered kinesin motor proteins amenable to small-molecule inhibition
title_fullStr	Engineered kinesin motor proteins amenable to small-molecule inhibition
title_full_unstemmed	Engineered kinesin motor proteins amenable to small-molecule inhibition
title_sort	engineered kinesin motor proteins amenable to small-molecule inhibition
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d400141931f143c5987411f968b209bc
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Engineered kinesin motor proteins amenable to small-molecule inhibition

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