Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons

Reduction in food intake elicits neuroendocrine adaptations to counterregulate the negative energy balance, e.g. via reduction in leptin levels. Here, the authors identify an additional starvation signal, growth hormone (GH). Blocking GH receptor attenuates the fall of whole body energy expenditure...

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Autores principales: Isadora C. Furigo, Pryscila D. S. Teixeira, Gabriel O. de Souza, Gisele C. L. Couto, Guadalupe García Romero, Mario Perelló, Renata Frazão, Lucila L. Elias, Martin Metzger, Edward O. List, John J. Kopchick, J. Donato
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d4067e42ca514c9c9b243f9101c626a6
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Sumario:Reduction in food intake elicits neuroendocrine adaptations to counterregulate the negative energy balance, e.g. via reduction in leptin levels. Here, the authors identify an additional starvation signal, growth hormone (GH). Blocking GH receptor attenuates the fall of whole body energy expenditure during food deprivation in mice.