Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System
Indoleamine-2,3-dioxygenase (IDO) is the “rate-limiting” enzyme in the kynurenine (Kyn) pathway of the tryptophan (Trp) catabolism. By its immune-modulatory effect, IDO initiates changes to the physiologically balanced immune state and plays a key role in the pathogenesis of various diseases, as wel...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:d408dbcc9d5d48d4819c7c08372be3fa2021-11-08T05:22:10ZIndoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System1664-042X10.3389/fphys.2021.766511https://doaj.org/article/d408dbcc9d5d48d4819c7c08372be3fa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.766511/fullhttps://doaj.org/toc/1664-042XIndoleamine-2,3-dioxygenase (IDO) is the “rate-limiting” enzyme in the kynurenine (Kyn) pathway of the tryptophan (Trp) catabolism. By its immune-modulatory effect, IDO initiates changes to the physiologically balanced immune state and plays a key role in the pathogenesis of various diseases, as well as in the perioperative setting during surgery. In autoimmune processes, highly malignant cancers such as glioblastoma or organ transplantation, IDO’s involvement has been studied extensively. However, in severe systemic infections, as present in sepsis, it is not yet completely understood. Hereafter, in this narrative review, we present the current knowledge of IDO’s implication on such complex immune-related processes. Moreover, we address the role of IDO as a predictive biomarker as well as a therapeutic target for immune-mediated diseases. Finally, we discuss IDO in the setting of surgical trauma-induced stress and highlight its promising use as a biomarker in the pre-operative setting for all disciplines involved in the decision-making process and treatment of patients undergoing surgery.Corina BelloCorina BelloPaul Philipp HeinischPaul Philipp HeinischMaks MihaljThierry CarrelMarkus M. LuediFrontiers Media S.A.articleimmune systemcardiac surgeryindoleamine-23-dioxygenasetryptophanimmunosuppressionPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
immune system cardiac surgery indoleamine-2 3-dioxygenase tryptophan immunosuppression Physiology QP1-981 |
| spellingShingle |
immune system cardiac surgery indoleamine-2 3-dioxygenase tryptophan immunosuppression Physiology QP1-981 Corina Bello Corina Bello Paul Philipp Heinisch Paul Philipp Heinisch Maks Mihalj Thierry Carrel Markus M. Luedi Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System |
| description |
Indoleamine-2,3-dioxygenase (IDO) is the “rate-limiting” enzyme in the kynurenine (Kyn) pathway of the tryptophan (Trp) catabolism. By its immune-modulatory effect, IDO initiates changes to the physiologically balanced immune state and plays a key role in the pathogenesis of various diseases, as well as in the perioperative setting during surgery. In autoimmune processes, highly malignant cancers such as glioblastoma or organ transplantation, IDO’s involvement has been studied extensively. However, in severe systemic infections, as present in sepsis, it is not yet completely understood. Hereafter, in this narrative review, we present the current knowledge of IDO’s implication on such complex immune-related processes. Moreover, we address the role of IDO as a predictive biomarker as well as a therapeutic target for immune-mediated diseases. Finally, we discuss IDO in the setting of surgical trauma-induced stress and highlight its promising use as a biomarker in the pre-operative setting for all disciplines involved in the decision-making process and treatment of patients undergoing surgery. |
| format |
article |
| author |
Corina Bello Corina Bello Paul Philipp Heinisch Paul Philipp Heinisch Maks Mihalj Thierry Carrel Markus M. Luedi |
| author_facet |
Corina Bello Corina Bello Paul Philipp Heinisch Paul Philipp Heinisch Maks Mihalj Thierry Carrel Markus M. Luedi |
| author_sort |
Corina Bello |
| title |
Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System |
| title_short |
Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System |
| title_full |
Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System |
| title_fullStr |
Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System |
| title_full_unstemmed |
Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System |
| title_sort |
indoleamine-2,3-dioxygenase as a perioperative marker of the immune system |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/d408dbcc9d5d48d4819c7c08372be3fa |
| work_keys_str_mv |
AT corinabello indoleamine23dioxygenaseasaperioperativemarkeroftheimmunesystem AT corinabello indoleamine23dioxygenaseasaperioperativemarkeroftheimmunesystem AT paulphilippheinisch indoleamine23dioxygenaseasaperioperativemarkeroftheimmunesystem AT paulphilippheinisch indoleamine23dioxygenaseasaperioperativemarkeroftheimmunesystem AT maksmihalj indoleamine23dioxygenaseasaperioperativemarkeroftheimmunesystem AT thierrycarrel indoleamine23dioxygenaseasaperioperativemarkeroftheimmunesystem AT markusmluedi indoleamine23dioxygenaseasaperioperativemarkeroftheimmunesystem |
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