Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

Lassa virus can cause haemorrhagic fever for which no specific treatment currently exists. Here the authors have cloned 113 monoclonal antibodies from the survivors of Lassa infection and show that the majority of neutralizing antibodies target a complex of GP1 and GP2 viral proteins.

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Autores principales:	James E. Robinson, Kathryn M. Hastie, Robert W. Cross, Rachael E. Yenni, Deborah H. Elliott, Julie A. Rouelle, Chandrika B. Kannadka, Ashley A. Smira, Courtney E. Garry, Benjamin T. Bradley, Haini Yu, Jeffrey G. Shaffer, Matt L. Boisen, Jessica N. Hartnett, Michelle A. Zandonatti, Megan M. Rowland, Megan L. Heinrich, Luis Martínez-Sobrido, Benson Cheng, Juan C. de la Torre, Kristian G. Andersen, Augustine Goba, Mambu Momoh, Mohamed Fullah, Michael Gbakie, Lansana Kanneh, Veronica J. Koroma, Richard Fonnie, Simbirie C. Jalloh, Brima Kargbo, Mohamed A. Vandi, Momoh Gbetuwa, Odia Ikponmwosa, Danny A. Asogun, Peter O. Okokhere, Onikepe A. Follarin, John S. Schieffelin, Kelly R. Pitts, Joan B. Geisbert, Peter C. Kulakoski, Russell B. Wilson, Christian T. Happi, Pardis C. Sabeti, Sahr M. Gevao, S. Humarr Khan, Donald S. Grant, Thomas W. Geisbert, Erica Ollmann Saphire, Luis M. Branco, Robert F. Garry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d40aae7302c442638a735c72e28f07c6
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spelling	oai:doaj.org-article:d40aae7302c442638a735c72e28f07c62021-12-02T15:35:41ZMost neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits10.1038/ncomms115442041-1723https://doaj.org/article/d40aae7302c442638a735c72e28f07c62016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11544https://doaj.org/toc/2041-1723Lassa virus can cause haemorrhagic fever for which no specific treatment currently exists. Here the authors have cloned 113 monoclonal antibodies from the survivors of Lassa infection and show that the majority of neutralizing antibodies target a complex of GP1 and GP2 viral proteins.James E. RobinsonKathryn M. HastieRobert W. CrossRachael E. YenniDeborah H. ElliottJulie A. RouelleChandrika B. KannadkaAshley A. SmiraCourtney E. GarryBenjamin T. BradleyHaini YuJeffrey G. ShafferMatt L. BoisenJessica N. HartnettMichelle A. ZandonattiMegan M. RowlandMegan L. HeinrichLuis Martínez-SobridoBenson ChengJuan C. de la TorreKristian G. AndersenAugustine GobaMambu MomohMohamed FullahMichael GbakieLansana KannehVeronica J. KoromaRichard FonnieSimbirie C. JallohBrima KargboMohamed A. VandiMomoh GbetuwaOdia IkponmwosaDanny A. AsogunPeter O. OkokhereOnikepe A. FollarinJohn S. SchieffelinKelly R. PittsJoan B. GeisbertPeter C. KulakoskiRussell B. WilsonChristian T. HappiPardis C. SabetiSahr M. GevaoS. Humarr KhanDonald S. GrantThomas W. GeisbertErica Ollmann SaphireLuis M. BrancoRobert F. GarryNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James E. Robinson Kathryn M. Hastie Robert W. Cross Rachael E. Yenni Deborah H. Elliott Julie A. Rouelle Chandrika B. Kannadka Ashley A. Smira Courtney E. Garry Benjamin T. Bradley Haini Yu Jeffrey G. Shaffer Matt L. Boisen Jessica N. Hartnett Michelle A. Zandonatti Megan M. Rowland Megan L. Heinrich Luis Martínez-Sobrido Benson Cheng Juan C. de la Torre Kristian G. Andersen Augustine Goba Mambu Momoh Mohamed Fullah Michael Gbakie Lansana Kanneh Veronica J. Koroma Richard Fonnie Simbirie C. Jalloh Brima Kargbo Mohamed A. Vandi Momoh Gbetuwa Odia Ikponmwosa Danny A. Asogun Peter O. Okokhere Onikepe A. Follarin John S. Schieffelin Kelly R. Pitts Joan B. Geisbert Peter C. Kulakoski Russell B. Wilson Christian T. Happi Pardis C. Sabeti Sahr M. Gevao S. Humarr Khan Donald S. Grant Thomas W. Geisbert Erica Ollmann Saphire Luis M. Branco Robert F. Garry Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
description	Lassa virus can cause haemorrhagic fever for which no specific treatment currently exists. Here the authors have cloned 113 monoclonal antibodies from the survivors of Lassa infection and show that the majority of neutralizing antibodies target a complex of GP1 and GP2 viral proteins.
format	article
author	James E. Robinson Kathryn M. Hastie Robert W. Cross Rachael E. Yenni Deborah H. Elliott Julie A. Rouelle Chandrika B. Kannadka Ashley A. Smira Courtney E. Garry Benjamin T. Bradley Haini Yu Jeffrey G. Shaffer Matt L. Boisen Jessica N. Hartnett Michelle A. Zandonatti Megan M. Rowland Megan L. Heinrich Luis Martínez-Sobrido Benson Cheng Juan C. de la Torre Kristian G. Andersen Augustine Goba Mambu Momoh Mohamed Fullah Michael Gbakie Lansana Kanneh Veronica J. Koroma Richard Fonnie Simbirie C. Jalloh Brima Kargbo Mohamed A. Vandi Momoh Gbetuwa Odia Ikponmwosa Danny A. Asogun Peter O. Okokhere Onikepe A. Follarin John S. Schieffelin Kelly R. Pitts Joan B. Geisbert Peter C. Kulakoski Russell B. Wilson Christian T. Happi Pardis C. Sabeti Sahr M. Gevao S. Humarr Khan Donald S. Grant Thomas W. Geisbert Erica Ollmann Saphire Luis M. Branco Robert F. Garry
author_facet	James E. Robinson Kathryn M. Hastie Robert W. Cross Rachael E. Yenni Deborah H. Elliott Julie A. Rouelle Chandrika B. Kannadka Ashley A. Smira Courtney E. Garry Benjamin T. Bradley Haini Yu Jeffrey G. Shaffer Matt L. Boisen Jessica N. Hartnett Michelle A. Zandonatti Megan M. Rowland Megan L. Heinrich Luis Martínez-Sobrido Benson Cheng Juan C. de la Torre Kristian G. Andersen Augustine Goba Mambu Momoh Mohamed Fullah Michael Gbakie Lansana Kanneh Veronica J. Koroma Richard Fonnie Simbirie C. Jalloh Brima Kargbo Mohamed A. Vandi Momoh Gbetuwa Odia Ikponmwosa Danny A. Asogun Peter O. Okokhere Onikepe A. Follarin John S. Schieffelin Kelly R. Pitts Joan B. Geisbert Peter C. Kulakoski Russell B. Wilson Christian T. Happi Pardis C. Sabeti Sahr M. Gevao S. Humarr Khan Donald S. Grant Thomas W. Geisbert Erica Ollmann Saphire Luis M. Branco Robert F. Garry
author_sort	James E. Robinson
title	Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
title_short	Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
title_full	Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
title_fullStr	Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
title_full_unstemmed	Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
title_sort	most neutralizing human monoclonal antibodies target novel epitopes requiring both lassa virus glycoprotein subunits
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d40aae7302c442638a735c72e28f07c6
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Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

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