A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease

Biljana Kuzmanović Elabjer, Leon Marković, Mirjana Bjelo&scaron;, Mladen Bu&scaron;ić, Daliborka Miletić, Eva Kos University Eye Clinic, Faculty of Dental Medicine and Health Care Osijek, Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, University Hospital &ldquo...

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Autores principales:	Kuzmanović Elabjer B, Marković L, Bjeloš M, Bušić M, Miletić D, Kos E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	dry eye disease inflammation topical preservative-free hydrocortisone corticosteroids central precorneal tear film ocular surface disease index Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d40b91fe4b0841a8b249ae41aade9f97
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spelling	oai:doaj.org-article:d40b91fe4b0841a8b249ae41aade9f972021-12-02T11:38:57ZA Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease1177-5483https://doaj.org/article/d40b91fe4b0841a8b249ae41aade9f972020-10-01T00:00:00Zhttps://www.dovepress.com/a-retrospective-data-review-confirms-that-topical-preservative-free-hy-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Biljana Kuzmanović Elabjer, Leon Marković, Mirjana Bjelo&scaron;, Mladen Bu&scaron;ić, Daliborka Miletić, Eva Kos University Eye Clinic, Faculty of Dental Medicine and Health Care Osijek, Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, University Hospital “Sveti Duh”, Zagreb, CroatiaCorrespondence: Mladen Bu&scaron;ićUniversity Eye Clinic, Faculty of Dental Medicine and Health Care Osijek, Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, University Hospital “Sveti Duh”, WHO Collaborating Centre for Child Eye Care, Sveti Duh 64, Zagreb 10 000, CroatiaTel +385913712167Email mbusic@kbsd.hrBackground: Inflammation is among the most important mechanisms in the pathogenesis of dry eye disease (DED), triggering the vicious circle of the disease. Reducing inflammation is an important target in dry eye disease treatment. Hydrocortisone is a low-potency corticosteroid with a low ocular penetration potential.Aim: To document the effect of topical preservative-free hydrocortisone 0.335% (PFH, Softacort®, Laboratoires Théa, France) on DED.Methods: Retrospective data review of patients with mild to moderate DED, treated with PFH for 15 days. Clinical evaluations at Days 0 and 15 included the assessment of the central precorneal tear film thickness (CPTFT), fluorescein tear breakup time, Schirmer test, corneal grading staining (Oxford schema), ocular surface disease index (OSDI) spatial distribution of the precorneal tear film thickness, intraocular pressure (IOP) and local tolerance.Results: Data from 13 women and 2 men were collected. Mean age±SD was 51± 5 years for women and 53± 4 years for men. Clinical signs and symptoms significantly (all p< 0.05) improved after 15 days of treatment. A significant positive correlation between the percentage of change in left eye CPTFT and that in the contralateral eye CPTFT was observed (p=0.003) as well as for both eyes and the left eye FTBUT (p=0.03). For the percentage of change in OSDI, the only significant correlation was with the percentage of change in right eye and FTBUT (p=0.03). IOP remained unchanged. No adverse events were recorded.Conclusion: This retrospective data review confirms that topical PFH twice daily for 2 weeks significantly improves clinical signs and symptoms in patients with mild to moderate DED with no safety issues.Keywords: dry eye disease, inflammation, topical preservative-free hydrocortisone, corticosteroids, central precorneal tear film, ocular surface disease indexKuzmanović Elabjer BMarković LBjeloš MBušić MMiletić DKos EDove Medical Pressarticledry eye diseaseinflammationtopical preservative-free hydrocortisonecorticosteroidscentral precorneal tear filmocular surface disease indexOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3691-3697 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye disease inflammation topical preservative-free hydrocortisone corticosteroids central precorneal tear film ocular surface disease index Ophthalmology RE1-994
spellingShingle	dry eye disease inflammation topical preservative-free hydrocortisone corticosteroids central precorneal tear film ocular surface disease index Ophthalmology RE1-994 Kuzmanović Elabjer B Marković L Bjeloš M Bušić M Miletić D Kos E A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease
description	Biljana Kuzmanović Elabjer, Leon Marković, Mirjana Bjelo&scaron;, Mladen Bu&scaron;ić, Daliborka Miletić, Eva Kos University Eye Clinic, Faculty of Dental Medicine and Health Care Osijek, Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, University Hospital “Sveti Duh”, Zagreb, CroatiaCorrespondence: Mladen Bu&scaron;ićUniversity Eye Clinic, Faculty of Dental Medicine and Health Care Osijek, Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, University Hospital “Sveti Duh”, WHO Collaborating Centre for Child Eye Care, Sveti Duh 64, Zagreb 10 000, CroatiaTel +385913712167Email mbusic@kbsd.hrBackground: Inflammation is among the most important mechanisms in the pathogenesis of dry eye disease (DED), triggering the vicious circle of the disease. Reducing inflammation is an important target in dry eye disease treatment. Hydrocortisone is a low-potency corticosteroid with a low ocular penetration potential.Aim: To document the effect of topical preservative-free hydrocortisone 0.335% (PFH, Softacort®, Laboratoires Théa, France) on DED.Methods: Retrospective data review of patients with mild to moderate DED, treated with PFH for 15 days. Clinical evaluations at Days 0 and 15 included the assessment of the central precorneal tear film thickness (CPTFT), fluorescein tear breakup time, Schirmer test, corneal grading staining (Oxford schema), ocular surface disease index (OSDI) spatial distribution of the precorneal tear film thickness, intraocular pressure (IOP) and local tolerance.Results: Data from 13 women and 2 men were collected. Mean age±SD was 51± 5 years for women and 53± 4 years for men. Clinical signs and symptoms significantly (all p< 0.05) improved after 15 days of treatment. A significant positive correlation between the percentage of change in left eye CPTFT and that in the contralateral eye CPTFT was observed (p=0.003) as well as for both eyes and the left eye FTBUT (p=0.03). For the percentage of change in OSDI, the only significant correlation was with the percentage of change in right eye and FTBUT (p=0.03). IOP remained unchanged. No adverse events were recorded.Conclusion: This retrospective data review confirms that topical PFH twice daily for 2 weeks significantly improves clinical signs and symptoms in patients with mild to moderate DED with no safety issues.Keywords: dry eye disease, inflammation, topical preservative-free hydrocortisone, corticosteroids, central precorneal tear film, ocular surface disease index
format	article
author	Kuzmanović Elabjer B Marković L Bjeloš M Bušić M Miletić D Kos E
author_facet	Kuzmanović Elabjer B Marković L Bjeloš M Bušić M Miletić D Kos E
author_sort	Kuzmanović Elabjer B
title	A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease
title_short	A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease
title_full	A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease
title_fullStr	A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease
title_full_unstemmed	A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease
title_sort	retrospective data review confirms that topical preservative-free hydrocortisone improves inflammation in dry eye disease
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d40b91fe4b0841a8b249ae41aade9f97
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A Retrospective Data Review Confirms That Topical Preservative-Free Hydrocortisone Improves Inflammation in Dry Eye Disease

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