COVID-19-associated coagulopathy in children and adolescents

The pandemic of the new coronavirus infection COVID-19 in 2020 has become the main health problem across the globe. A special characteristic of the SARSCoV-2 virus is tropism to the vascular endothelium with the development of endotheliitis, which entails a number of typical disorders of the blood...

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Autores principales:	M. V. Gomellya, A. V. Tatarinova, T. S. Krupskaya, L. V. Rychkova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	covid-19 сhildren hemostasis coagulopathy anticoagulants Science Q
Acceso en línea:	https://doaj.org/article/d40d1993abbe41ae977c5f5e70e9c759
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spelling	oai:doaj.org-article:d40d1993abbe41ae977c5f5e70e9c7592021-11-23T06:14:46ZCOVID-19-associated coagulopathy in children and adolescents2541-94202587-959610.29413/ABS.2021-6.3.15https://doaj.org/article/d40d1993abbe41ae977c5f5e70e9c7592021-08-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2858https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The pandemic of the new coronavirus infection COVID-19 in 2020 has become the main health problem across the globe. A special characteristic of the SARSCoV-2 virus is tropism to the vascular endothelium with the development of endotheliitis, which entails a number of typical disorders of the blood coagulation system: coagulopathy with increased thrombin generation, D-dimer, decreased fibrinolysis and prolonged prothrombin time. The coagulation disorder in COVID-19 is called thromboinflammation. Hyperinflammation, increased blood levels of von Willebrand factor, coagulation factor VIII, neutrophil extracellular traps, platelet activation, microvesicles play a significant role in the pathogenesis of hypercoagulation in COVID-19. To date, it is known that cases of COVID-19 in children and adolescents constitute a small part of the total number of patients with diagnosed COVID-19, and disorders of the blood coagulation system are similar to those in adults. The degree of hypercoagulable syndrome and the risk of thrombosis depend on the severity of COVID-19. And for children they are most expressed with the development of a hyperinflammatory immune response, called multisystem inflammatory syndrome. At the same time, clinical studies of the pathogenesis of COVID-19 in adults and children and the search for optimal methods of therapy for thrombus inflammation, which underlies the pathogenesis of COVID-19, continue.M. V. GomellyaA. V. TatarinovaT. S. KrupskayaL. V. RychkovaScientific Сentre for Family Health and Human Reproduction Problemsarticlecovid-19сhildrenhemostasiscoagulopathyanticoagulantsScienceQRUActa Biomedica Scientifica, Vol 6, Iss 3, Pp 142-153 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	covid-19 сhildren hemostasis coagulopathy anticoagulants Science Q
spellingShingle	covid-19 сhildren hemostasis coagulopathy anticoagulants Science Q M. V. Gomellya A. V. Tatarinova T. S. Krupskaya L. V. Rychkova COVID-19-associated coagulopathy in children and adolescents
description	The pandemic of the new coronavirus infection COVID-19 in 2020 has become the main health problem across the globe. A special characteristic of the SARSCoV-2 virus is tropism to the vascular endothelium with the development of endotheliitis, which entails a number of typical disorders of the blood coagulation system: coagulopathy with increased thrombin generation, D-dimer, decreased fibrinolysis and prolonged prothrombin time. The coagulation disorder in COVID-19 is called thromboinflammation. Hyperinflammation, increased blood levels of von Willebrand factor, coagulation factor VIII, neutrophil extracellular traps, platelet activation, microvesicles play a significant role in the pathogenesis of hypercoagulation in COVID-19. To date, it is known that cases of COVID-19 in children and adolescents constitute a small part of the total number of patients with diagnosed COVID-19, and disorders of the blood coagulation system are similar to those in adults. The degree of hypercoagulable syndrome and the risk of thrombosis depend on the severity of COVID-19. And for children they are most expressed with the development of a hyperinflammatory immune response, called multisystem inflammatory syndrome. At the same time, clinical studies of the pathogenesis of COVID-19 in adults and children and the search for optimal methods of therapy for thrombus inflammation, which underlies the pathogenesis of COVID-19, continue.
format	article
author	M. V. Gomellya A. V. Tatarinova T. S. Krupskaya L. V. Rychkova
author_facet	M. V. Gomellya A. V. Tatarinova T. S. Krupskaya L. V. Rychkova
author_sort	M. V. Gomellya
title	COVID-19-associated coagulopathy in children and adolescents
title_short	COVID-19-associated coagulopathy in children and adolescents
title_full	COVID-19-associated coagulopathy in children and adolescents
title_fullStr	COVID-19-associated coagulopathy in children and adolescents
title_full_unstemmed	COVID-19-associated coagulopathy in children and adolescents
title_sort	covid-19-associated coagulopathy in children and adolescents
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/d40d1993abbe41ae977c5f5e70e9c759
work_keys_str_mv	AT mvgomellya covid19associatedcoagulopathyinchildrenandadolescents AT avtatarinova covid19associatedcoagulopathyinchildrenandadolescents AT tskrupskaya covid19associatedcoagulopathyinchildrenandadolescents AT lvrychkova covid19associatedcoagulopathyinchildrenandadolescents
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COVID-19-associated coagulopathy in children and adolescents

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