Dynamical origins of heat capacity changes in enzyme-catalysed reactions

Heat capacity changes affect the temperature dependence of enzyme catalysis, with implications for thermoadaptation, however their physical basis is unknown. Here the authors show that heat capacity changes are calculable by simulation, revealing distinct dynamical contributions from regions remote...

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Autores principales:	Marc W. van der Kamp, Erica J. Prentice, Kirsty L. Kraakman, Michael Connolly, Adrian J. Mulholland, Vickery L. Arcus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d40e1dcd15e6492cbf102e64d92191d2
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spelling	oai:doaj.org-article:d40e1dcd15e6492cbf102e64d92191d22021-12-02T15:33:40ZDynamical origins of heat capacity changes in enzyme-catalysed reactions10.1038/s41467-018-03597-y2041-1723https://doaj.org/article/d40e1dcd15e6492cbf102e64d92191d22018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03597-yhttps://doaj.org/toc/2041-1723Heat capacity changes affect the temperature dependence of enzyme catalysis, with implications for thermoadaptation, however their physical basis is unknown. Here the authors show that heat capacity changes are calculable by simulation, revealing distinct dynamical contributions from regions remote from the active site.Marc W. van der KampErica J. PrenticeKirsty L. KraakmanMichael ConnollyAdrian J. MulhollandVickery L. ArcusNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marc W. van der Kamp Erica J. Prentice Kirsty L. Kraakman Michael Connolly Adrian J. Mulholland Vickery L. Arcus Dynamical origins of heat capacity changes in enzyme-catalysed reactions
description	Heat capacity changes affect the temperature dependence of enzyme catalysis, with implications for thermoadaptation, however their physical basis is unknown. Here the authors show that heat capacity changes are calculable by simulation, revealing distinct dynamical contributions from regions remote from the active site.
format	article
author	Marc W. van der Kamp Erica J. Prentice Kirsty L. Kraakman Michael Connolly Adrian J. Mulholland Vickery L. Arcus
author_facet	Marc W. van der Kamp Erica J. Prentice Kirsty L. Kraakman Michael Connolly Adrian J. Mulholland Vickery L. Arcus
author_sort	Marc W. van der Kamp
title	Dynamical origins of heat capacity changes in enzyme-catalysed reactions
title_short	Dynamical origins of heat capacity changes in enzyme-catalysed reactions
title_full	Dynamical origins of heat capacity changes in enzyme-catalysed reactions
title_fullStr	Dynamical origins of heat capacity changes in enzyme-catalysed reactions
title_full_unstemmed	Dynamical origins of heat capacity changes in enzyme-catalysed reactions
title_sort	dynamical origins of heat capacity changes in enzyme-catalysed reactions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d40e1dcd15e6492cbf102e64d92191d2
work_keys_str_mv	AT marcwvanderkamp dynamicaloriginsofheatcapacitychangesinenzymecatalysedreactions AT ericajprentice dynamicaloriginsofheatcapacitychangesinenzymecatalysedreactions AT kirstylkraakman dynamicaloriginsofheatcapacitychangesinenzymecatalysedreactions AT michaelconnolly dynamicaloriginsofheatcapacitychangesinenzymecatalysedreactions AT adrianjmulholland dynamicaloriginsofheatcapacitychangesinenzymecatalysedreactions AT vickerylarcus dynamicaloriginsofheatcapacitychangesinenzymecatalysedreactions
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Dynamical origins of heat capacity changes in enzyme-catalysed reactions

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