Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.

<h4>Background</h4>The prevalence of transmitted HIV drug resistance (TDR) is stabilizing or decreasing in developed countries. However, this trend is not specifically evaluated among immigrants from regions without well-implemented antiretroviral strategies.<h4>Methods</h4>T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gonzalo Yebra, Miguel de Mulder, María Jesús Pérez-Elías, José Antonio Pérez-Molina, Juan Carlos Galán, Jara Llenas-García, Santiago Moreno, África Holguín
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d40eee54933042d4b1a4e0f6567019f6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d40eee54933042d4b1a4e0f6567019f6
record_format	dspace
spelling	oai:doaj.org-article:d40eee54933042d4b1a4e0f6567019f62021-11-18T07:35:47ZIncrease of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.1932-620310.1371/journal.pone.0026757https://doaj.org/article/d40eee54933042d4b1a4e0f6567019f62011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22046345/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The prevalence of transmitted HIV drug resistance (TDR) is stabilizing or decreasing in developed countries. However, this trend is not specifically evaluated among immigrants from regions without well-implemented antiretroviral strategies.<h4>Methods</h4>TDR trends during 1996-2010 were analyzed among naïve HIV-infected patients in Spain, considering their origin and other factors. TDR mutations were defined according to the World Health Organization list.<h4>Results</h4>Pol sequence was available for 732 HIV-infected patients: 292 native Spanish, 226 sub-Saharan Africans (SSA), 114 Central-South Americans (CSA) and 100 from other regions. Global TDR prevalence was 9.7% (10.6% for Spanish, 8.4% for SSA and 7.9% for CSA). The highest prevalences were found for protease inhibitors (PI) in Spanish (3.1%), for non-nucleoside reverse transcriptase inhibitors (NNRTI) in SSA (6.5%) and for nucleoside reverse transcriptase inhibitors (NRTI) in both Spanish and SSA (6.5%). The global TDR rate decreased from 11.3% in 2004-2006 to 8.4% in 2007-2010. Characteristics related to a decreasing TDR trend in 2007-10 were Spanish and CSA origin, NRTI- and NNRTI-resistance, HIV-1 subtype B, male sex and infection through injection drug use. TDR remained stable for PI-resistance, in patients infected through sexual intercourse and in those carrying non-B variants. However, TDR increased among SSA and females. K103N was the predominant mutation in all groups and periods.<h4>Conclusion</h4>TDR prevalence tended to decrease among HIV-infected native Spanish and Central-South Americans, but it increased up to 13% in sub-Saharan immigrants in 2007-2010. These results highlight the importance of a specific TDR surveillance among immigrants to prevent future therapeutic failures, especially when administering NNRTIs.Gonzalo YebraMiguel de MulderMaría Jesús Pérez-ElíasJosé Antonio Pérez-MolinaJuan Carlos GalánJara Llenas-GarcíaSantiago MorenoÁfrica HolguínPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26757 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gonzalo Yebra Miguel de Mulder María Jesús Pérez-Elías José Antonio Pérez-Molina Juan Carlos Galán Jara Llenas-García Santiago Moreno África Holguín Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.
description	<h4>Background</h4>The prevalence of transmitted HIV drug resistance (TDR) is stabilizing or decreasing in developed countries. However, this trend is not specifically evaluated among immigrants from regions without well-implemented antiretroviral strategies.<h4>Methods</h4>TDR trends during 1996-2010 were analyzed among naïve HIV-infected patients in Spain, considering their origin and other factors. TDR mutations were defined according to the World Health Organization list.<h4>Results</h4>Pol sequence was available for 732 HIV-infected patients: 292 native Spanish, 226 sub-Saharan Africans (SSA), 114 Central-South Americans (CSA) and 100 from other regions. Global TDR prevalence was 9.7% (10.6% for Spanish, 8.4% for SSA and 7.9% for CSA). The highest prevalences were found for protease inhibitors (PI) in Spanish (3.1%), for non-nucleoside reverse transcriptase inhibitors (NNRTI) in SSA (6.5%) and for nucleoside reverse transcriptase inhibitors (NRTI) in both Spanish and SSA (6.5%). The global TDR rate decreased from 11.3% in 2004-2006 to 8.4% in 2007-2010. Characteristics related to a decreasing TDR trend in 2007-10 were Spanish and CSA origin, NRTI- and NNRTI-resistance, HIV-1 subtype B, male sex and infection through injection drug use. TDR remained stable for PI-resistance, in patients infected through sexual intercourse and in those carrying non-B variants. However, TDR increased among SSA and females. K103N was the predominant mutation in all groups and periods.<h4>Conclusion</h4>TDR prevalence tended to decrease among HIV-infected native Spanish and Central-South Americans, but it increased up to 13% in sub-Saharan immigrants in 2007-2010. These results highlight the importance of a specific TDR surveillance among immigrants to prevent future therapeutic failures, especially when administering NNRTIs.
format	article
author	Gonzalo Yebra Miguel de Mulder María Jesús Pérez-Elías José Antonio Pérez-Molina Juan Carlos Galán Jara Llenas-García Santiago Moreno África Holguín
author_facet	Gonzalo Yebra Miguel de Mulder María Jesús Pérez-Elías José Antonio Pérez-Molina Juan Carlos Galán Jara Llenas-García Santiago Moreno África Holguín
author_sort	Gonzalo Yebra
title	Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.
title_short	Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.
title_full	Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.
title_fullStr	Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.
title_full_unstemmed	Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.
title_sort	increase of transmitted drug resistance among hiv-infected sub-saharan africans residing in spain in contrast to the native population.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/d40eee54933042d4b1a4e0f6567019f6
work_keys_str_mv	AT gonzaloyebra increaseoftransmitteddrugresistanceamonghivinfectedsubsaharanafricansresidinginspainincontrasttothenativepopulation AT migueldemulder increaseoftransmitteddrugresistanceamonghivinfectedsubsaharanafricansresidinginspainincontrasttothenativepopulation AT mariajesusperezelias increaseoftransmitteddrugresistanceamonghivinfectedsubsaharanafricansresidinginspainincontrasttothenativepopulation AT joseantonioperezmolina increaseoftransmitteddrugresistanceamonghivinfectedsubsaharanafricansresidinginspainincontrasttothenativepopulation AT juancarlosgalan increaseoftransmitteddrugresistanceamonghivinfectedsubsaharanafricansresidinginspainincontrasttothenativepopulation AT jarallenasgarcia increaseoftransmitteddrugresistanceamonghivinfectedsubsaharanafricansresidinginspainincontrasttothenativepopulation AT santiagomoreno increaseoftransmitteddrugresistanceamonghivinfectedsubsaharanafricansresidinginspainincontrasttothenativepopulation AT africaholguin increaseoftransmitteddrugresistanceamonghivinfectedsubsaharanafricansresidinginspainincontrasttothenativepopulation
_version_	1718423253166325760

Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.

Ejemplares similares