FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS
Functional characteristics of neutrophils were evaluated in fifty-two patients with severe form ofchronic recurrent furunculosis, i.e., intensity of oxygen- and nitric oxide production, apoptosis rates, NET-forming properties, as well as phagocytic and bactericidal capacity. We have detected reduced...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2014
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/d40f4eb95d9e43a0940cca9c0999578e |
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| Sumario: | Functional characteristics of neutrophils were evaluated in fifty-two patients with severe form ofchronic recurrent furunculosis, i.e., intensity of oxygen- and nitric oxide production, apoptosis rates, NET-forming properties, as well as phagocytic and bactericidal capacity. We have detected reduced efficiency ofintracellular pathogen killing, accompanied by a suppression of oxygen- and nitric oxide-producing reserve ofneutrophils. A compensatory increase in functional reserve of NET formation activity was also revealed, thusbeing a potential extracellular bactericidal mechanism for neutrophils. At the time of the disease exacerbation,we have found a decreased readiness for both spontaneous and stimulated neutrophil apoptosis. |
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