FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS

Functional characteristics of neutrophils were evaluated in fifty-two patients with severe form ofchronic recurrent furunculosis, i.e., intensity of oxygen- and nitric oxide production, apoptosis rates, NET-forming properties, as well as phagocytic and bactericidal capacity. We have detected reduced...

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Autores principales:	I. A. Novikovа, N, V. Gusakova, A. V. Hamaliaka
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	neutrophils functional activity chronic furunculosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d40f4eb95d9e43a0940cca9c0999578e
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spelling	oai:doaj.org-article:d40f4eb95d9e43a0940cca9c0999578e2021-11-18T08:03:37ZFUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS1563-06252313-741X10.15789/1563-0625-2014-1-81-88https://doaj.org/article/d40f4eb95d9e43a0940cca9c0999578e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/28https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XFunctional characteristics of neutrophils were evaluated in fifty-two patients with severe form ofchronic recurrent furunculosis, i.e., intensity of oxygen- and nitric oxide production, apoptosis rates, NET-forming properties, as well as phagocytic and bactericidal capacity. We have detected reduced efficiency ofintracellular pathogen killing, accompanied by a suppression of oxygen- and nitric oxide-producing reserve ofneutrophils. A compensatory increase in functional reserve of NET formation activity was also revealed, thusbeing a potential extracellular bactericidal mechanism for neutrophils. At the time of the disease exacerbation,we have found a decreased readiness for both spontaneous and stimulated neutrophil apoptosis.I. A. NovikovаN, V. GusakovaA. V. HamaliakaSPb RAACIarticleneutrophilsfunctional activitychronic furunculosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 1, Pp 81-88 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	neutrophils functional activity chronic furunculosis Immunologic diseases. Allergy RC581-607
spellingShingle	neutrophils functional activity chronic furunculosis Immunologic diseases. Allergy RC581-607 I. A. Novikovа N, V. Gusakova A. V. Hamaliaka FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS
description	Functional characteristics of neutrophils were evaluated in fifty-two patients with severe form ofchronic recurrent furunculosis, i.e., intensity of oxygen- and nitric oxide production, apoptosis rates, NET-forming properties, as well as phagocytic and bactericidal capacity. We have detected reduced efficiency ofintracellular pathogen killing, accompanied by a suppression of oxygen- and nitric oxide-producing reserve ofneutrophils. A compensatory increase in functional reserve of NET formation activity was also revealed, thusbeing a potential extracellular bactericidal mechanism for neutrophils. At the time of the disease exacerbation,we have found a decreased readiness for both spontaneous and stimulated neutrophil apoptosis.
format	article
author	I. A. Novikovа N, V. Gusakova A. V. Hamaliaka
author_facet	I. A. Novikovа N, V. Gusakova A. V. Hamaliaka
author_sort	I. A. Novikovа
title	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS
title_short	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS
title_full	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS
title_fullStr	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS
title_full_unstemmed	FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS
title_sort	functional activity of neutrophils in chronic recurrent furunculosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/d40f4eb95d9e43a0940cca9c0999578e
work_keys_str_mv	AT ianovikova functionalactivityofneutrophilsinchronicrecurrentfurunculosis AT nvgusakova functionalactivityofneutrophilsinchronicrecurrentfurunculosis AT avhamaliaka functionalactivityofneutrophilsinchronicrecurrentfurunculosis
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FUNCTIONAL ACTIVITY OF NEUTROPHILS IN CHRONIC RECURRENT FURUNCULOSIS

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