Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.

While metabolic syndrome (MetS) is associated with frailty, the correlation of serum lactate dehydrogenase (sLDH) and frailty with MetS remain uncertain. To investigate the relationship between sLDH and frail components in the US with MetS. A total of 4,066 participants aged 40-90 years were assesse...

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Autores principales:	Li-Hsiang Chen, Li-Wei Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d411d06f9537461db3bb513c049c57c0
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spelling	oai:doaj.org-article:d411d06f9537461db3bb513c049c57c02021-12-02T20:08:32ZAssociation between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.1932-620310.1371/journal.pone.0256315https://doaj.org/article/d411d06f9537461db3bb513c049c57c02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256315https://doaj.org/toc/1932-6203While metabolic syndrome (MetS) is associated with frailty, the correlation of serum lactate dehydrogenase (sLDH) and frailty with MetS remain uncertain. To investigate the relationship between sLDH and frail components in the US with MetS. A total of 4,066 participants aged 40-90 years were assessed from the database of the third National Health and Nutrition Examination Survey, 1988-1994. The participants were classified into MetS and non-MetS groups. Multivariate logistic regression analysis with four models were performed to assess the odds ratio (OR) of the divided tertiles of sLDH levels with frailty, and frail components including slow walking (SW), weakness, exhaustion, low physical activity (LPA), and low body weight (LBW). Higher sLDH levels were positively associated with frailty in the MetS group (p = 0.024) but not in non-MetS group (p = 0.102). After covariate adjustments, the OR of frailty in the upper two tertiles compared to the lowest tertile and revealed statistical significance (p < 0.05). Frail components of SW, weakness, exhaustion, and LPA were associated with higher sLDH (p < 0.05) except for LBW in MetS and non-MetS groups. The results demonstrated the strong association of higher sLDH levels and frailty among US individuals with MetS.Li-Hsiang ChenLi-Wei WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256315 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li-Hsiang Chen Li-Wei Wu Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.
description	While metabolic syndrome (MetS) is associated with frailty, the correlation of serum lactate dehydrogenase (sLDH) and frailty with MetS remain uncertain. To investigate the relationship between sLDH and frail components in the US with MetS. A total of 4,066 participants aged 40-90 years were assessed from the database of the third National Health and Nutrition Examination Survey, 1988-1994. The participants were classified into MetS and non-MetS groups. Multivariate logistic regression analysis with four models were performed to assess the odds ratio (OR) of the divided tertiles of sLDH levels with frailty, and frail components including slow walking (SW), weakness, exhaustion, low physical activity (LPA), and low body weight (LBW). Higher sLDH levels were positively associated with frailty in the MetS group (p = 0.024) but not in non-MetS group (p = 0.102). After covariate adjustments, the OR of frailty in the upper two tertiles compared to the lowest tertile and revealed statistical significance (p < 0.05). Frail components of SW, weakness, exhaustion, and LPA were associated with higher sLDH (p < 0.05) except for LBW in MetS and non-MetS groups. The results demonstrated the strong association of higher sLDH levels and frailty among US individuals with MetS.
format	article
author	Li-Hsiang Chen Li-Wei Wu
author_facet	Li-Hsiang Chen Li-Wei Wu
author_sort	Li-Hsiang Chen
title	Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.
title_short	Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.
title_full	Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.
title_fullStr	Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.
title_full_unstemmed	Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.
title_sort	association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d411d06f9537461db3bb513c049c57c0
work_keys_str_mv	AT lihsiangchen associationbetweenserumlactatedehydrogenaseandfrailtyamongindividualswithmetabolicsyndrome AT liweiwu associationbetweenserumlactatedehydrogenaseandfrailtyamongindividualswithmetabolicsyndrome
_version_	1718375210346872832

Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.

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