Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease

Combined treatments using polyphenols and omega fatty acids provide several therapeutic benefits for a variety of age-related disorders, including Alzheimer’s disease (AD). Previously, we found a commercial product, Total Body Rhythm (TBR), consisting of tart cherry extract, a potent polyphenol, and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zackary Bowers, Panchanan Maiti, Ali Bourcier, Jarod Morse, Kenneth Jenrow, Julien Rossignol, Gary L. Dunbar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease neurodegeneration inflammation 5xFAD total body rhythm antioxidants Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/d41465ab940f4102985e24aeb272ed1b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d41465ab940f4102985e24aeb272ed1b
record_format	dspace
spelling	oai:doaj.org-article:d41465ab940f4102985e24aeb272ed1b2021-11-25T16:56:55ZTart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease10.3390/brainsci111114232076-3425https://doaj.org/article/d41465ab940f4102985e24aeb272ed1b2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1423https://doaj.org/toc/2076-3425Combined treatments using polyphenols and omega fatty acids provide several therapeutic benefits for a variety of age-related disorders, including Alzheimer’s disease (AD). Previously, we found a commercial product, Total Body Rhythm (TBR), consisting of tart cherry extract, a potent polyphenol, and omega fatty acids, significantly reduced memory, and neuropathological deficits in the 192 IgG-saporin mouse model of AD. The present study assessed the efficacy of TBR for treating behavioral and neuropathological deficits in the 5xFAD model of AD. Both 6- and 12-month-old 5xFAD mice and age-matched wild-type controls received TBR (60 mg/kg) or the equivalent dose of vehicle (0.5% methylcellulose) via oral administration, every other day for two months. All mice were tested in the open field (OF), novel object recognition (NOR), and the Morris water maze (MWM) tasks. In addition, neuronal morphology, neurodegeneration, Aβ plaque load, and glial activation were assessed. TBR treatment reduced memory deficits in the MWM and NOR tests and lessened anxiety levels in the OF task, mostly in the 6-month-old male mice. TBR also protected against neuron loss, reduced activation of astrocytes and microglia, primarily in 6-month-old mice, and attenuated Aβ deposition. These results suggest that the combination of tart cherry extract and omega fatty acids in TBR can reduce AD-like deficits in 5xFAD mice.Zackary BowersPanchanan MaitiAli BourcierJarod MorseKenneth JenrowJulien RossignolGary L. DunbarMDPI AGarticleAlzheimer’s diseaseneurodegenerationinflammation5xFADtotal body rhythmantioxidantsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1423, p 1423 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease neurodegeneration inflammation 5xFAD total body rhythm antioxidants Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Alzheimer’s disease neurodegeneration inflammation 5xFAD total body rhythm antioxidants Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Zackary Bowers Panchanan Maiti Ali Bourcier Jarod Morse Kenneth Jenrow Julien Rossignol Gary L. Dunbar Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease
description	Combined treatments using polyphenols and omega fatty acids provide several therapeutic benefits for a variety of age-related disorders, including Alzheimer’s disease (AD). Previously, we found a commercial product, Total Body Rhythm (TBR), consisting of tart cherry extract, a potent polyphenol, and omega fatty acids, significantly reduced memory, and neuropathological deficits in the 192 IgG-saporin mouse model of AD. The present study assessed the efficacy of TBR for treating behavioral and neuropathological deficits in the 5xFAD model of AD. Both 6- and 12-month-old 5xFAD mice and age-matched wild-type controls received TBR (60 mg/kg) or the equivalent dose of vehicle (0.5% methylcellulose) via oral administration, every other day for two months. All mice were tested in the open field (OF), novel object recognition (NOR), and the Morris water maze (MWM) tasks. In addition, neuronal morphology, neurodegeneration, Aβ plaque load, and glial activation were assessed. TBR treatment reduced memory deficits in the MWM and NOR tests and lessened anxiety levels in the OF task, mostly in the 6-month-old male mice. TBR also protected against neuron loss, reduced activation of astrocytes and microglia, primarily in 6-month-old mice, and attenuated Aβ deposition. These results suggest that the combination of tart cherry extract and omega fatty acids in TBR can reduce AD-like deficits in 5xFAD mice.
format	article
author	Zackary Bowers Panchanan Maiti Ali Bourcier Jarod Morse Kenneth Jenrow Julien Rossignol Gary L. Dunbar
author_facet	Zackary Bowers Panchanan Maiti Ali Bourcier Jarod Morse Kenneth Jenrow Julien Rossignol Gary L. Dunbar
author_sort	Zackary Bowers
title	Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease
title_short	Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease
title_full	Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease
title_fullStr	Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease
title_full_unstemmed	Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease
title_sort	tart cherry extract and omega fatty acids reduce behavioral deficits, gliosis, and amyloid-beta deposition in the 5xfad mouse model of alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d41465ab940f4102985e24aeb272ed1b
work_keys_str_mv	AT zackarybowers tartcherryextractandomegafattyacidsreducebehavioraldeficitsgliosisandamyloidbetadepositioninthe5xfadmousemodelofalzheimersdisease AT panchananmaiti tartcherryextractandomegafattyacidsreducebehavioraldeficitsgliosisandamyloidbetadepositioninthe5xfadmousemodelofalzheimersdisease AT alibourcier tartcherryextractandomegafattyacidsreducebehavioraldeficitsgliosisandamyloidbetadepositioninthe5xfadmousemodelofalzheimersdisease AT jarodmorse tartcherryextractandomegafattyacidsreducebehavioraldeficitsgliosisandamyloidbetadepositioninthe5xfadmousemodelofalzheimersdisease AT kennethjenrow tartcherryextractandomegafattyacidsreducebehavioraldeficitsgliosisandamyloidbetadepositioninthe5xfadmousemodelofalzheimersdisease AT julienrossignol tartcherryextractandomegafattyacidsreducebehavioraldeficitsgliosisandamyloidbetadepositioninthe5xfadmousemodelofalzheimersdisease AT garyldunbar tartcherryextractandomegafattyacidsreducebehavioraldeficitsgliosisandamyloidbetadepositioninthe5xfadmousemodelofalzheimersdisease
_version_	1718412864330399744

Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease

Ejemplares similares