Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics
Enkhjargal Bayarsaikhan,1,2,* Delger Bayarsaikhan,1,* Jaesuk Lee,1 Myeongjoo Son,1,3 Seyeon Oh,1 Jeongsik Moon,1 Hye-Jeong Park,1 Arivazhagan Roshini,1 Seung U Kim,4 Byoung-Joon Song,5 Seung-Mook Jo,6 Kyunghee Byun,1,3 Bonghee Lee1,3 1Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes...
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Dove Medical Press
2016
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oai:doaj.org-article:d41588e312ab4eac8d154bd63dbab6a22021-12-02T03:05:26ZMicroglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics1178-2013https://doaj.org/article/d41588e312ab4eac8d154bd63dbab6a22016-08-01T00:00:00Zhttps://www.dovepress.com/microglial-age-albumin-is-critical-for-neuronal-death-in-parkinson39s--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Enkhjargal Bayarsaikhan,1,2,* Delger Bayarsaikhan,1,* Jaesuk Lee,1 Myeongjoo Son,1,3 Seyeon Oh,1 Jeongsik Moon,1 Hye-Jeong Park,1 Arivazhagan Roshini,1 Seung U Kim,4 Byoung-Joon Song,5 Seung-Mook Jo,6 Kyunghee Byun,1,3 Bonghee Lee1,3 1Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea; 2Department of General Laboratory, National Cancer Center of Mongolia, Ulaanbaatar, Mongolia; 3Department of Anatomy and Cell Biology, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea; 4Department of Medicine, University of British Columbia, Vancouver, Canada; 5Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA; 6Department of Emergency Medical Services, Eulji University, Seongnam-si, Gyeonggi-do, Republic of Korea *These authors contributed equally to this work Abstract: Advanced glycation end products (AGEs) are known to play an important role in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD), by inducing protein aggregation and cross-link, formation of Lewy body, and neuronal death. In this study, we observed that AGE-albumin, the most abundant AGE product in the human PD brain, is synthesized in activated microglial cells and accumulates in the extracellular space. AGE-albumin synthesis in human-activated microglial cells is distinctly inhibited by ascorbic acid and cytochalasin treatment. Accumulated AGE-albumin upregulates the receptor to AGE, leading to apoptosis of human primary dopamine (DA) neurons. In animal experiments, we observed reduced DA neuronal cell death by treatment with soluble receptor to AGE. Our study provides evidence that activated microglial cells are one of the main contributors in AGE-albumin accumulation, deleterious to DA neurons in human and animal PD brains. Finally, activated microglial AGE-albumin could be used as a diagnostic and therapeutic biomarker with high sensitivity for neurodegenerative disorders, including PD. Keywords: theragnostic, microglia, AGE-albumin, neuronal death, receptor of AGE, Parkinson’s diseaseBayarsaikhan EBayarsaikhan DLee JSon MOh SMoon JPark HJRoshini AKim SUSong BJJo SMByun KLee B,Dove Medical PressarticletheragnosticmicrogliaAGE-albuminneuronal deathRAGEParkinson's diseaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 10, Pp 281-292 (2016) |
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theragnostic microglia AGE-albumin neuronal death RAGE Parkinson's disease Medicine (General) R5-920 |
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theragnostic microglia AGE-albumin neuronal death RAGE Parkinson's disease Medicine (General) R5-920 Bayarsaikhan E Bayarsaikhan D Lee J Son M Oh S Moon J Park HJ Roshini A Kim SU Song BJ Jo SM Byun K Lee B, Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics |
| description |
Enkhjargal Bayarsaikhan,1,2,* Delger Bayarsaikhan,1,* Jaesuk Lee,1 Myeongjoo Son,1,3 Seyeon Oh,1 Jeongsik Moon,1 Hye-Jeong Park,1 Arivazhagan Roshini,1 Seung U Kim,4 Byoung-Joon Song,5 Seung-Mook Jo,6 Kyunghee Byun,1,3 Bonghee Lee1,3 1Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea; 2Department of General Laboratory, National Cancer Center of Mongolia, Ulaanbaatar, Mongolia; 3Department of Anatomy and Cell Biology, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea; 4Department of Medicine, University of British Columbia, Vancouver, Canada; 5Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA; 6Department of Emergency Medical Services, Eulji University, Seongnam-si, Gyeonggi-do, Republic of Korea *These authors contributed equally to this work Abstract: Advanced glycation end products (AGEs) are known to play an important role in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD), by inducing protein aggregation and cross-link, formation of Lewy body, and neuronal death. In this study, we observed that AGE-albumin, the most abundant AGE product in the human PD brain, is synthesized in activated microglial cells and accumulates in the extracellular space. AGE-albumin synthesis in human-activated microglial cells is distinctly inhibited by ascorbic acid and cytochalasin treatment. Accumulated AGE-albumin upregulates the receptor to AGE, leading to apoptosis of human primary dopamine (DA) neurons. In animal experiments, we observed reduced DA neuronal cell death by treatment with soluble receptor to AGE. Our study provides evidence that activated microglial cells are one of the main contributors in AGE-albumin accumulation, deleterious to DA neurons in human and animal PD brains. Finally, activated microglial AGE-albumin could be used as a diagnostic and therapeutic biomarker with high sensitivity for neurodegenerative disorders, including PD. Keywords: theragnostic, microglia, AGE-albumin, neuronal death, receptor of AGE, Parkinson’s disease |
| format |
article |
| author |
Bayarsaikhan E Bayarsaikhan D Lee J Son M Oh S Moon J Park HJ Roshini A Kim SU Song BJ Jo SM Byun K Lee B, |
| author_facet |
Bayarsaikhan E Bayarsaikhan D Lee J Son M Oh S Moon J Park HJ Roshini A Kim SU Song BJ Jo SM Byun K Lee B, |
| author_sort |
Bayarsaikhan E |
| title |
Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics |
| title_short |
Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics |
| title_full |
Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics |
| title_fullStr |
Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics |
| title_full_unstemmed |
Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics |
| title_sort |
microglial age-albumin is critical for neuronal death in parkinson's disease: a possible implication for theranostics |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/d41588e312ab4eac8d154bd63dbab6a2 |
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