Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?

In obesity, several epigenetic modifications, including histones remodeling, DNA methylation, and microRNAs, could accumulate and determine increased expression of inflammatory molecules, the adipokines, that in turn might induce or accelerate the onset and development of cardiovascular and metaboli...

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Autores principales:	Rosaria Anna Fontanella, Lucia Scisciola, Maria Rosaria Rizzo, Surina Surina, Celestino Sardu, Raffaele Marfella, Giuseppe Paolisso, Michelangela Barbieri
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adiponectin obesity inflammation epigenetic mechanisms cardiovascular complications Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/d416983594244c76a62899f831103657
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spelling	oai:doaj.org-article:d416983594244c76a62899f8311036572021-11-19T05:27:47ZAdiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?2297-055X10.3389/fcvm.2021.768026https://doaj.org/article/d416983594244c76a62899f8311036572021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.768026/fullhttps://doaj.org/toc/2297-055XIn obesity, several epigenetic modifications, including histones remodeling, DNA methylation, and microRNAs, could accumulate and determine increased expression of inflammatory molecules, the adipokines, that in turn might induce or accelerate the onset and development of cardiovascular and metabolic disorders. In order to better clarify the potential epigenetic mechanisms underlying the modulation of the inflammatory response by adipokines, the DNA methylation profile in peripheral leukocytes of the promoter region of IL-6 and NF-kB genes and plasma miRNA-21 levels were evaluated in 356 healthy subjects, using quantitative pyrosequencing-based analysis, and correlated with plasma adiponectin levels, body fat content and the primary pro-inflammatory markers. In addition, correlation analysis of DNA methylation profiles and miRNA-21 plasma levels with intima-media thickness (IMT), a surrogate marker for early atherosclerosis, left ventricular mass (LVM), left ventricular ejection fraction (LVEF), and cardiac performance index (MPI) was also performed to evaluate any potential clinical implication in terms of cardiovascular outcome. Results achieved confirmed the role of epigenetics in the obesity-related cardiovascular complications and firstly supported the potential role of plasma miRNA-21 and IL-6 and NF-kB DNA methylation changes in nucleated blood cells as potential biomarkers for predicting cardiovascular risk in obesity. Furthermore, our results, showing a role of adiponectin in preventing epigenetic modification induced by increased adipose tissue content in obese subjects, provide new evidence of an additional mechanism underlying the anti-inflammatory properties and the cardiovascular benefits of adiponectin. The exact mechanisms underlying the obesity-related epigenetic modifications found in the blood cells and whether similar epigenetic changes reflect adipose and myocardial tissue modifications need to be further investigated in future experiments.Rosaria Anna FontanellaLucia ScisciolaMaria Rosaria RizzoSurina SurinaCelestino SarduRaffaele MarfellaRaffaele MarfellaGiuseppe PaolissoGiuseppe PaolissoMichelangela BarbieriFrontiers Media S.A.articleadiponectinobesityinflammationepigenetic mechanismscardiovascular complicationsDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adiponectin obesity inflammation epigenetic mechanisms cardiovascular complications Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	adiponectin obesity inflammation epigenetic mechanisms cardiovascular complications Diseases of the circulatory (Cardiovascular) system RC666-701 Rosaria Anna Fontanella Lucia Scisciola Maria Rosaria Rizzo Surina Surina Celestino Sardu Raffaele Marfella Raffaele Marfella Giuseppe Paolisso Giuseppe Paolisso Michelangela Barbieri Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?
description	In obesity, several epigenetic modifications, including histones remodeling, DNA methylation, and microRNAs, could accumulate and determine increased expression of inflammatory molecules, the adipokines, that in turn might induce or accelerate the onset and development of cardiovascular and metabolic disorders. In order to better clarify the potential epigenetic mechanisms underlying the modulation of the inflammatory response by adipokines, the DNA methylation profile in peripheral leukocytes of the promoter region of IL-6 and NF-kB genes and plasma miRNA-21 levels were evaluated in 356 healthy subjects, using quantitative pyrosequencing-based analysis, and correlated with plasma adiponectin levels, body fat content and the primary pro-inflammatory markers. In addition, correlation analysis of DNA methylation profiles and miRNA-21 plasma levels with intima-media thickness (IMT), a surrogate marker for early atherosclerosis, left ventricular mass (LVM), left ventricular ejection fraction (LVEF), and cardiac performance index (MPI) was also performed to evaluate any potential clinical implication in terms of cardiovascular outcome. Results achieved confirmed the role of epigenetics in the obesity-related cardiovascular complications and firstly supported the potential role of plasma miRNA-21 and IL-6 and NF-kB DNA methylation changes in nucleated blood cells as potential biomarkers for predicting cardiovascular risk in obesity. Furthermore, our results, showing a role of adiponectin in preventing epigenetic modification induced by increased adipose tissue content in obese subjects, provide new evidence of an additional mechanism underlying the anti-inflammatory properties and the cardiovascular benefits of adiponectin. The exact mechanisms underlying the obesity-related epigenetic modifications found in the blood cells and whether similar epigenetic changes reflect adipose and myocardial tissue modifications need to be further investigated in future experiments.
format	article
author	Rosaria Anna Fontanella Lucia Scisciola Maria Rosaria Rizzo Surina Surina Celestino Sardu Raffaele Marfella Raffaele Marfella Giuseppe Paolisso Giuseppe Paolisso Michelangela Barbieri
author_facet	Rosaria Anna Fontanella Lucia Scisciola Maria Rosaria Rizzo Surina Surina Celestino Sardu Raffaele Marfella Raffaele Marfella Giuseppe Paolisso Giuseppe Paolisso Michelangela Barbieri
author_sort	Rosaria Anna Fontanella
title	Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?
title_short	Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?
title_full	Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?
title_fullStr	Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?
title_full_unstemmed	Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?
title_sort	adiponectin related vascular and cardiac benefits in obesity: is there a role for an epigenetically regulated mechanism?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d416983594244c76a62899f831103657
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Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?

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