Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial

Objective: To compare the efficacy of tamsulosin, silodosin, and silodosin plus tadalafil as medical expulsive therapy (MET) for distal ureteric calculi. Methods: In all, 120 patients who met the inclusion criteria were randomised into one of three treatment arms: tamsulosin (Group A), silodosin (Gr...

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Autores principales:	Md Jawaid Rahman, M. Shazib Faridi, Naloh Mibang, Rajendra Sinam Singh
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Efficacy Silodosin Tadalafil Tamsulosin Ureteric calculi Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/d41712547e6d4f768b12b2124a66cc1a
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spelling	oai:doaj.org-article:d41712547e6d4f768b12b2124a66cc1a2021-12-02T10:12:19ZComparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial2090-598X10.1016/j.aju.2017.11.012https://doaj.org/article/d41712547e6d4f768b12b2124a66cc1a2018-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17301468https://doaj.org/toc/2090-598XObjective: To compare the efficacy of tamsulosin, silodosin, and silodosin plus tadalafil as medical expulsive therapy (MET) for distal ureteric calculi. Methods: In all, 120 patients who met the inclusion criteria were randomised into one of three treatment arms: tamsulosin (Group A), silodosin (Group B), and silodosin plus tadalafil (Group C). The drugs were given for a maximum of 4 weeks. The primary endpoint was the stone expulsion rate and secondary endpoints were stone expulsion time, number of pain episodes, and side-effects associated with MET. The follow-up period was for 4 weeks, after which ureteroscopic lithotripsy was done to remove any stones that were not expelled. Results: There was a statistically significantly higher stone expulsion rate in Group C (90%) as compared to groups A (57.5%) and B (77.5%) with a shorter mean time to stone expulsion. Also, there were statistically fewer pain episodes in Group C as compared to groups A and B. There were no serious side-effects. Conclusion: The present study concludes that the combination of silodosin and tadalafil increases the ureteric stone expulsion rate and decreases the expulsion time significantly. This combination provided significantly better control of pain without any serious side-effects.Md Jawaid RahmanM. Shazib FaridiNaloh MibangRajendra Sinam SinghTaylor & Francis GrouparticleEfficacySilodosinTadalafilTamsulosinUreteric calculiDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 2, Pp 245-249 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Efficacy Silodosin Tadalafil Tamsulosin Ureteric calculi Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Efficacy Silodosin Tadalafil Tamsulosin Ureteric calculi Diseases of the genitourinary system. Urology RC870-923 Md Jawaid Rahman M. Shazib Faridi Naloh Mibang Rajendra Sinam Singh Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial
description	Objective: To compare the efficacy of tamsulosin, silodosin, and silodosin plus tadalafil as medical expulsive therapy (MET) for distal ureteric calculi. Methods: In all, 120 patients who met the inclusion criteria were randomised into one of three treatment arms: tamsulosin (Group A), silodosin (Group B), and silodosin plus tadalafil (Group C). The drugs were given for a maximum of 4 weeks. The primary endpoint was the stone expulsion rate and secondary endpoints were stone expulsion time, number of pain episodes, and side-effects associated with MET. The follow-up period was for 4 weeks, after which ureteroscopic lithotripsy was done to remove any stones that were not expelled. Results: There was a statistically significantly higher stone expulsion rate in Group C (90%) as compared to groups A (57.5%) and B (77.5%) with a shorter mean time to stone expulsion. Also, there were statistically fewer pain episodes in Group C as compared to groups A and B. There were no serious side-effects. Conclusion: The present study concludes that the combination of silodosin and tadalafil increases the ureteric stone expulsion rate and decreases the expulsion time significantly. This combination provided significantly better control of pain without any serious side-effects.
format	article
author	Md Jawaid Rahman M. Shazib Faridi Naloh Mibang Rajendra Sinam Singh
author_facet	Md Jawaid Rahman M. Shazib Faridi Naloh Mibang Rajendra Sinam Singh
author_sort	Md Jawaid Rahman
title	Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial
title_short	Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial
title_full	Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial
title_fullStr	Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial
title_full_unstemmed	Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial
title_sort	comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: a randomised trial
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/d41712547e6d4f768b12b2124a66cc1a
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Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial

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